Evidence map›Paper›PMID 40356754›Full record

SynthesisFrontiers in oncology2025

Opportunities and limits of open partial horizontal laryngectomies for naïve T3-T4a laryngeal cancer: a systematic review and meta-analysis.

Erika Crosetti, Andrea Lorenzi, Carmine Prizio, Andrea Elio Sprio, Marco Fantini, Alice Azizi Semeskandi, Andy Bertolin, Giulia Arrigoni, Giovanni Succo

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erika CrosettiENT University Clinic - Head and Neck Cancer Unit, San Giovanni Bosco Hospital, Turin, Italy.
Andrea LorenziDepartment of Surgical Science, University of Turin, Turin, Italy.
Carmine PrizioDepartment of Surgical Science, University of Turin, Turin, Italy.
Andrea Elio SprioDepartment of Research, ASOMI College of Sciences, Marsa, Malta.
Marco FantiniENT University Clinic - Head and Neck Cancer Unit, San Giovanni Bosco Hospital, Turin, Italy.
Alice Azizi SemeskandiDepartment of Surgical Science, University of Turin, Turin, Italy.
Andy BertolinOtorhinolaryngology Unit, Vittorio Veneto Hospital, Azienda Unità Locale Socio Sanitaria n. 2. (AULSS2) Treviso, Vittorio Veneto, Italy.
Giulia ArrigoniENT University Clinic - Head and Neck Cancer Unit, San Giovanni Bosco Hospital, Turin, Italy.
Giovanni SuccoENT University Clinic - Head and Neck Cancer Unit, San Giovanni Bosco Hospital, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The present systematic review aims to investigate the survival rates and surgical outcomes of patients with treatment-naïve, intermediate (T3) to early advanced (T4a) laryngeal squamous cell carcinoma (LSCC) managed with open partial horizontal laryngectomies (OPHLs). Methods: A systematic literature search was conducted in PubMed, Embase, and Scopus for studies published between January 2000 and December 2023. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Inclusion criteria were: patients with histopathological confirmed LSCC; tumor classified as T3 or T4a stage according to the American Joint Committee on Cancer (AJCC) staging system; having undergone OPHL as the primary treatment without any prior therapy; availability of at least one of the following outcomes: overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), local control (LC), locoregional control (LRC), laryngectomy-free survival (LFS), and laryngo-esophageal dysfunction-free survival (LEDFS). Results: A total of 16 studies were deemed eligible for the qualitative analysis. The cumulative number of patients was 1473. The sample size ranged from 17 to 390 patients. The follow-up period ranged from 0 to 198 months. In patients treated with OPHL for T3, the overall five-year pooled proportions were OS 0.82, DSS 0.88, DFS 0.80, and LFS 0.86, whereas for the T4a case series, they were OS 0.77, DSS 0.89, DFS 0.74, and LFS 0.78. Conclusions: OPHL for selected T3 and low extralaryngeal volume T4a LSCC can guarantee a high rate of oncological success. Accurate patient selection is paramount to differentiate advanced diseases that is amenable to conservative surgery.

Indexed as

laryngeal cancerlaryngeal preservationLSCCopen partial horizontal laryngectomypartial laryngectomyT3 laryngeal cancerT4 laryngeal cancer

Identifiers

PMID40356754
PMCPMC12066441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.