Evidence map›Paper›PMID 40356721›Full record

ArticleFrontiers in molecular biosciences2025

Layla A Almutairi, Amal S Abu-Almakarem, Noorah Saleh Al-Sowayan, Sahar Abdulrahman Alkhodair, Hayat M Albishi, Thamir M Eid, Fahad A Alshanbari, Najlaa Yousef Abuzinadah, Maysa A Mobasher, Karim Samy El-Said

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Layla A AlmutairiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Amal S Abu-AlmakaremDepartment of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.
Noorah Saleh Al-SowayanDepartment of Biology, College of Science, Qassim University, Buraidah, Saudi Arabia.
Sahar Abdulrahman AlkhodairDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Hayat M AlbishiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Thamir M EidDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Fahad A AlshanbariDepartment of Medical Biosciences, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
Najlaa Yousef AbuzinadahDepartment of Biological Science, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Maysa A MobasherDepartment of Pathology, Biochemistry Division, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Karim Samy El-SaidBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: The phytochemical, GC/MS profiling, and metal chelation ability of CSE were evaluated. Molecular docking studies were performed using AutoDock Vina. The oral LD Results: The results demonstrate that CSE exerted a pronounced metal-chelating activity Conclusion: This study for the first time investigated the biochemical and molecular mechanisms regarding the effects of CSE treatment on PbAc-induced testicular damage in male rats. CSE showed potential attenuative effect on the testis injury induced by PbAc treatment by targeting JAK2/STAT3, and NLRP3/Caspase-1 pathways. These findings suggest that CSE could be used against the adverse effect of PbAc on male repro-toxicity.

Indexed as

anti-inflammatoryantioxidantBrown algaeColpomenia sinuosaleadtesticular dysfunctions

Identifiers

PMID40356721
PMCPMC12066309

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.