ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Correlations Between TyG-Related Indices and Bone Health: A Cross-Sectional Study of Osteoporosis in a Rural Chinese Population.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- TyG-BMI as a Marker of Metabolic Status and Its Association with Bone Quality and Mineral Metabolism: A Sex-Specific Analysis.Journal of clinical medicine · 2026Article
- The relationship between the polymorphisms and mutations of OPG gene and bone metabolism in postmenopausal women in northwest China.Journal of orthopaedic surgery and research · 2026Article
- Linear Inverse Association Between Triglyceride Glucose-Body Mass Index and Osteoporosis in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Relationship Between Serum Melatonin Levels and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- Association of triglyceride glucose body mass index with osteoporosis risks in a large Chinese adult cohort.Frontiers in endocrinology · 2025Article
- Development and external validation of models to improve prediction of osteoporosis in elderly women: interpretable machine learning.Frontiers in endocrinology · 2025Article
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7 authors.
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Abstract
Background: Osteoporosis (OP) is a major metabolic bone disease with significant health and socioeconomic impacts. The triglyceride-glucose (TyG) index and its derivatives, which reflect insulin resistance (IR), may play a role in bone metabolism. However, the relationship between TyG indices and OP is unclear. This study aimed to explore the association between TyG indices and OP in a low-income rural Chinese population. Methods: This cross-sectional study was conducted in rural Tianjin, China, in 2020. Participants aged 60 years or older were included. Data were collected through interviews, including sociodemographic and clinical information, and physical examinations. Bone mineral density (BMD) of the femoral neck was measured using dual-energy X-ray absorptiometry (DXA). Multivariate regression models and restricted cubic spline (RCS) curves were used to assess the relationships between TyG indices and OP. Results: A total of 437 individuals were included in the final analysis, with 38 diagnosed with osteoporosis (prevalence of 8.7%). After adjusting for all covariates, each 1-unit increase in triglyceride-glucose-body mass index (TyG-BMI) was associated with a 2% lower risk of osteoporosis, (OR: 0.98, 95% CI: 0.96-1.00, P=0.029), especially in women, individuals with hypertension, and non-diabetic populations. The OP risk of the fourth quartile (Q4) of the triglyceride-glucose-waist circumference (TyG-WC) index after correcting for all covariates is 5.58 times that of the first quartile (Q1)(OR: 5.58, 95% CI: 1.14-27.41, P=0.034). Linear regression showed a positive correlation between TyG-BMI and BMD, particularly in women, individuals under 70, and those with hypertension or non-hypertension, with the strongest correlation in the non-hypertensive group. Conclusion: TyG-related indices are associated with OP, suggesting a potential role in the early prevention and management of osteoporosis in this population, ultimately improving public health outcomes.
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