ArticleFrontiers in neuroscience2025
Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson's disease.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Nonmotor Symptoms in Parkinson's Disease: Neurophysiology Biomarkers and Neuromodulation Approaches.Stereotactic and functional neurosurgery · 2026Review
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10 authors.
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Abstract
Objective: STN-DBS is an effective treatment for Parkinson's disease (PD), improving motor symptoms, but its impact on non-motor symptoms, such as anxiety and depression, remain unclear. This study investigates the relationship between electrode contact locations, their corresponding volume of tissue activated (VTA), and postoperative changes in emotional symptoms. It aims to identify optimal group-level stimulation sites for improving anxiety and depression in PD patients and to develop a structural connectome to explore how cortical regions targeted by fiber projections correlate with mood outcomes. Methods: We retrospectively studied 56 PD patients who underwent bilateral STN-DBS, assessed 6 months post-surgery. Standardized scales evaluated motor, affective, and cognitive symptoms before and after the procedure. Electrode positions were reconstructed using Lead-DBS, and VTAs were calculated. Voxel-wise sweet spot and structural connectivity analyses investigated how stimulation sites influenced clinical outcomes. Results: Compared to preoperative assessments, postoperative evaluations revealed varying degrees of improvement in motor function, quality of life, and symptoms of anxiety and depression in PD patients ( Conclusion: STN-DBS markedly improves motor symptoms and quality of life in PD patients while also positively impacting anxiety and depressive symptoms. The ventral STN is likely the optimal stimulation target for ameliorating anxiety and depressive symptoms. The therapeutic effects of STN-DBS electrodes may promote postoperative improvements in anxiety and depression by modulating fiber tracts connected to prefrontal regions. Future research should leverage connectome mapping and isolated fiber tracts to refine electrode placement, using directional leads to target specific STN subregions for improved symptom management.
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