ArticlePlastic and reconstructive surgery. Global open2025
Does Aspirin Increase Risk of Bleeding in Patients Undergoing Skin Lesion Excision: A Systematic Review and Meta-Analysis.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Aspirin is a commonly prescribed medication, which impairs the action of platelets. This also results in a higher risk of bleeding. Cutaneous lesion excision is frequently performed for diagnosis and treatment of malignancies, as well as for aesthetic or functional benefits. We must balance the risk of bleeding against the risk of discontinuing aspirin. We conducted a systematic review, and meta-analysis, in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines to evaluate the evidence of postoperative bleeding risk conferred by continuation of aspirin in cutaneous surgery. Methods: A systematic search of the literature was performed. Included studies evaluated the incidence of hemorrhage or hematoma in adults undergoing cutaneous surgery. The following participant characteristics were noted: age, sex, surgical site, and type of wound closure performed. A random-effects model was chosen to calculate the effect size-expressed as odds ratio (OR) with a 95% confidence interval-for bleeding of any severity, moderate severity, severe severity, infection, and wound dehiscence (outcomes). Results: A total of 26,860 procedures were included from 20 studies. A statistically significant increase in odds of bleeding of any severity (16,748 procedures included) OR 1.39 (1.02-1.90) and for bleeding of severe severity (12,311 procedures included) OR 2.46 (1.53-3.95) was identified. Moderate severity bleeding (1629 procedures included) OR 0.92 (0.46-1.81), infection OR 0.60 (0.28-1.28), and wound dehiscence OR 0.92 (0.41-2.06) effect size results did not attain statistical significance. Conclusions: Our analysis identified a statistically significant increase in postoperative bleeding risk for patients taking aspirin and undergoing cutaneous surgery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.