Evidence map›Paper›PMID 40356498›Full record

ArticleHistology and histopathology2026

Expression of mucins MUC1 and MUC4 in curative resected gallbladder adenocarcinoma.

Masako Noumi, Michiyo Higashi, Ikumi Kitazono, Seiya Yokoyama, Takashi Tasaki, Hirotsugu Noguchi, Mari Kirishima, Miki Murakami, Akihide Tanimoto

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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Masako NoumiDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Michiyo HigashiDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Ikumi KitazonoDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Seiya YokoyamaDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Takashi TasakiDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hirotsugu NoguchiDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Mari KirishimaDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Miki MurakamiDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Akihide TanimotoDepartment of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Funding

Grants-in-Aid for Scientific Research on Scientific Research 18K07326
6 · The paper itself

Abstract

BACKGROUND AND

aimsGallbladder adenocarcinoma (GBAC) is associated with high mortality because of the difficulty in its early detection and treatment. Therefore, identifying prognostic factors is crucial for managing patients with GBAC. We aimed to elucidate the relationship between immunohistochemical profiles of mucin expression, clinicopathological behavior, and prognosis for curatively resected gallbladder adenocarcinoma (GBAC) and to prove that mucin expression is a prognostic factor for GBAC.

methodsWe examined the expression of mucins (MUC1, MUC2, and MUC4) using immunohistochemical analyses and compared the prevalence of each mucin with clinicopathological features in patients with early-stage (stage 0 to IIB) GBAC.

resultsMUC1 expression was significantly expressed in patients with GBAC with lymphatic invasion, vascular invasion, perineural invasion, and recurrence. MUC2 was significantly expressed in patients with GBAC with perineural invasion and recurrence but not with prognosis. Patients with MUC1-high expression exhibited worse prognoses than those with MUC1-low expression. In contrast, patients with positive MUC4 expression had significantly better prognoses than those without MUC4 expression.

conclusionThe expression of MUC1 and MUC4 in GBAC is an independent prognostic factor for survival and a useful marker for predicting the outcomes of patients with GBAC.

Indexed as

AdenocarcinomaBiomarkers, TumorGallbladder NeoplasmsMucin-1Mucin-4AdultAgedAged, 80 and overFemaleHumansImmunohistochemistryMaleMiddle AgedPrognosisBiomarkers, TumorMUC1 protein, humanMUC4 protein, humanMucin-1Mucin-4

Identifiers

PMID40356498

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