Evidence map›Paper›PMID 40356480›Full record

ArticleJournal of neurochemistry2025

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice.

Itsumi Nagai-Arakawa, Ikunobu Muramatsu, Junsuke Uwada, Yo Tsuda, Akinori Tokunaga, Ai Irie, Hideyuki Maeda, Yuta Madokoro, Toyohiro Sato, Yuto Uchida and 5 more

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Itsumi Nagai-ArakawaDepartment of Neurology, Nagoya City University Graduate School of Medicine, Nagoya, Aichi, Japan.
Ikunobu MuramatsuDepartment of Genomic Science and Microbiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.ORCID 0000-0002-6881-5391
Junsuke UwadaDepartment of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Yo TsudaDepartment of Neurology, Nagoya City University Graduate School of Medicine, Nagoya, Aichi, Japan.
Akinori TokunagaDivision of Laboratory Animal Resources, Life Science Support Center, University of Fukui, Fukui, Japan.ORCID 0000-0001-9560-0516
Ai IrieDivision of Laboratory Animal Resources, Life Science Support Center, University of Fukui, Fukui, Japan.
Hideyuki MaedaDivision of Laboratory Animal Resources, Life Science Support Center, University of Fukui, Fukui, Japan.
Yuta MadokoroDepartment of Neurology, Nagoya City University Graduate School of Medicine, Nagoya, Aichi, Japan.
Toyohiro SatoDepartment of Neurology, Nagoya City University Graduate School of Medicine, Nagoya, Aichi, Japan.
Yuto UchidaDepartment of Neurology, Nagoya City University Graduate School of Medicine, Nagoya, Aichi, Japan.
Takashi SaitoDepartment of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan.
Kiyonao SadaDepartment of Genomic Science and Microbiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Takayoshi MasuokaDepartment of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Noriyuki MatsukawaDepartment of Neurology, Nagoya City University Graduate School of Medicine, Nagoya, Aichi, Japan.ORCID 0000-0002-6638-4516

Funding

Japan Society for the Promotion of Science 22K06637Smocking Research Foundation 2021G008
6 · The paper itself

Abstract

A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission. However, the precise mechanisms contributing to cholinergic dysfunction are not fully elucidated. Herein, we evaluated the cholinergic system in wild type (WT) mice and AD-model (App

Indexed as

AcetylcholineAgingAmyloid beta-Protein PrecursorCholinergic NeuronsSynaptic TransmissionAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCholineGene Knock-In TechniquesHippocampusMaleMiceMice, Inbred C57BLMice, TransgenicSymportersAcetylcholineAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCholineSymportersacetylcholineagingAlzheimer's diseasecholinergic

Identifiers

PMID40356480
PMCPMC12070134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.