Evidence map›Paper›PMID 40356391›Full record

ArticleRecent advances in anti-infective drug discovery2025

Deciphering Plasmodium Condensin Core Subunits of Structural Maintenance of Chromosomes 2 (SMC2) as a Putative Drug Target for Antimalarial Drug.

Uma Chauhan, Manali Datta, Sanket Kaushik, Vinay Sharma, Sakshi Piplani, Ravi Ranjan Kumar Niraj

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Article in Recent advances in anti-infective drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Uma ChauhanAmity Institute of Biotechnology, Amity University, Rajasthan, Jaipur, India.
Manali DattaAmity Institute of Biotechnology, Amity University, Rajasthan, Jaipur, India.
Sanket KaushikAmity Institute of Biotechnology, Amity University, Rajasthan, Jaipur, India.
Vinay SharmaAmity Institute of Biotechnology, Amity University, Rajasthan, Jaipur, India.
Sakshi PiplaniVaxine Pty Ltd, Warradale, Australia.
Ravi Ranjan Kumar NirajAmity Institute of Biotechnology, Amity University, Rajasthan, Jaipur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe structural maintenance of chromosomes (SMC) proteins plays a noteworthy role in chromosome dynamics. Several recent studies reported that the condensin core subunits of structural maintenance of chromosomes 2 (SMC2) play important roles in the atypical mitosis of the Plasmodium life cycle and may perform different functions during different proliferative stages. For eukaryotes, the structural maintenance of chromosomes (SMC) proteins are divided into six subunits and form three heterodimers of structural maintenance of chromosomes (SMC1/3) cohesion complex, structural maintenance of chromosomes (SMC2/4) condensin complex, and structural maintenance of chromosomes (SMC5/6) complex for chromosome cohesion, condensation, and DNA damage repair, respectively.

objectiveThe objective of this study was to investigate the structural maintenance of chromosomes 2 (SMC2) protein of

methodsIn this study, we investigated the structural maintenance of chromosomes 2 (SMC2) protein of

resultsWe reported the structural maintenance of chromosomes 2 (SMC2) protein of

conclusion

Indexed as

Adenosine TriphosphatasesAntimalarialsDNA-Binding ProteinsMultiprotein ComplexesPlasmodium falciparumProtozoan ProteinsHumansMalaria, FalciparumMolecular Docking SimulationAdenosine TriphosphatasesAntimalarialscondensin complexesDNA-Binding ProteinsMultiprotein ComplexesProtozoan Proteinscodensindrug target.in-silicoMalariaplasmodiumstructural maintenance of chromosomes 2 (SMC2)

Identifiers

PMID40356391

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