Evidence map›Paper›PMID 40356389›Full record

ReviewRecent advances in anti-infective drug discovery2025

Bedaquiline Delivery Innovations: A Review on Advancing MDR-TB Treatment Strategies.

Asad Ahmad, Juber Akhtar, Mohammad Ahmad, Badruddeen, Mohammad Irfan Khan, Aditya Singh, Anas Islam

Abstract readReview
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In one paragraph

Review in Recent advances in anti-infective drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Asad AhmadFaculty of Pharmacy, Integral University, Lucknow, 226026, India.
Juber AkhtarFaculty of Pharmacy, Integral University, Lucknow, 226026, India.
Mohammad AhmadFaculty of Pharmacy, Integral University, Lucknow, 226026, India.
BadruddeenFaculty of Pharmacy, Integral University, Lucknow, 226026, India.
Mohammad Irfan KhanFaculty of Pharmacy, Integral University, Lucknow, 226026, India.
Aditya SinghFaculty of Pharmacy, Integral University, Lucknow, 226026, India.
Anas IslamFaculty of Pharmacy, Integral University, Lucknow, 226026, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant tuberculosis (MDR-TB) poses a persistent challenge to global health, necessitating continuous efforts to enhance treatment efficacy. Bedaquiline, a cornerstone in MDR-TB management, presents biopharmaceutical challenges that impact its therapeutic potential. This review provides a comprehensive analysis of recent innovations in drug delivery strategies designed to optimize Bedaquiline's efficacy and improve MDR-TB treatment outcomes. Through a systematic examination of various delivery systems, including nanotechnology and formulation advancements, we explore their potential in addressing drug solubility and bioavailability challenges. Emphasizing the integration of Quality by Design (QbD) principles, this review aims to present a cohesive overview of evolving Bedaquiline delivery innovations, providing valuable insights for researchers and healthcare practitioners working towards advancing MDR-TB treatment strategies.

Indexed as

Antitubercular AgentsDiarylquinolinesDrug Delivery SystemsTuberculosis, Multidrug-ResistantBiological AvailabilityHumansAntitubercular AgentsbedaquilineDiarylquinolinesBedaquilinebioavailability drug deliveryMDR-TB Treatment.multidrug resistancesystematictuberculosis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.