Evidence map›Paper›PMID 40356374›Full record

ArticleJournal of Alzheimer's disease : JAD2025

High precision and cost-effective multiplex quantification of amyloid-β40, amyloid-β42, p181Tau, p217Tau, neurofilament light chain, and glial fibrillary acidic protein from plasma and serum.

Farshad Alishahi, Christopher R Beam, Margaret Gatz, Lon S Schneider, Daniel A Nation, Hussein N Yassine, Hillard Kaplan, Suchita Ganesan, Ioannis Pappas, Deborah Winders Davis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Farshad AlishahiUniversity of Southern California, Los Angeles, CA, USA.ORCID 0009-0008-0097-5082
Christopher R BeamUniversity of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-6827-409X
Margaret GatzUniversity of Southern California, Los Angeles, CA, USA.
Lon S SchneiderUniversity of Southern California, Los Angeles, CA, USA.
Daniel A NationUniversity of Southern California, Los Angeles, CA, USA.
Hussein N YassineUniversity of Southern California, Los Angeles, CA, USA.
Hillard KaplanEconomic Science Institute, Argyros College of Business and Economics, Chapman University, Orange, CA, USA.
Suchita GanesanUniversity of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-3814-3053
Ioannis PappasUniversity of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0168-7014
Deborah Winders DavisDepartment of Pediatrics, University of Louisville School of Medicine, and Norton Children's Research Institute affiliated with the University of Louisville School of Medicine, Louisville, KY, USA.ORCID 0000-0002-5943-3877
Ebrahim ZandiUniversity of Southern California, Los Angeles, CA, USA.ORCID 0009-0008-9506-2437

Funding

Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American PopulationsR01AG054442 · NIA · CHAPMAN UNIVERSITY · PI CALEB E FINCH, Margaret Gatz · 2022 to 2026
$15.2M
Past, Present, and Future Risk of Cognitive Decline and Cognitive Impairment in the Louisville Twin StudyR01AG063949 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher Ryan Beam, DEBORAH WINDERS DAVIS · 2019 to 2026
$7.8M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS R01 AG054442NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG063949
6 · The paper itself

Abstract

BackgroundCurrent methods to quantify blood biomarkers for Alzheimer's disease (AD) are expensive and are not widely available.ObjectiveTo develop a low-cost, sensitive, and accurate multiplex assay to quantify Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesGlial Fibrillary Acidic ProteinNeurofilament ProteinsPeptide FragmentsAgedAged, 80 and overBiomarkersCognitive DysfunctionCohort StudiesCost-Benefit AnalysisFemaleHumansMaleMiddle AgedROC CurveAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)amyloid beta-protein (40-42)BiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsAlzheimer's diseaseamyloid-betabiomarkersbloodtau

Identifiers

PMID40356374
PMCPMC12964561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.