ArticleBrain and behavior2025
Mediating Role of Depression Severity in the Relationship Between Childhood Trauma and Non-Suicidal Self-Injury Among Adolescents With Mood Disorders.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of influencing factors of non-suicidal self-injury behavior in adolescents with depression.Frontiers in psychiatry · 2026Pooled it
- Psychosocial and Biological Factors Associated with Non-Suicidal Self-Injury in Chinese Child and Adolescent Inpatients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2026Article
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3 authors.
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Abstract
objectiveNon-suicidal self-injury (NSSI) frequently co-occurs with childhood trauma (CT) and depression; however, their interplay and underlying mechanisms are not fully understood. This article explores the nuanced relationships between these factors and their impact on NSSI, offering practical insights for the prevention and intervention of childhood post-traumatic depression progression and NSSI among adolescents.
methodsThe present study leveraged the Childhood Trauma Questionnaire (CTQ), the Adolescent Non-suicidal Self-injury Assessment Questionnaire (ANSAQ), and the Hamilton Rating Scale for Depression (HAMD) to assess a cohort of 361 individuals with mood disorders. The study design was cross-sectional, and a convenience sampling method was utilized. The mediation effect was tested using the Process stepwise regression method, and the significance of the mediation effect was assessed through Bootstrap analysis.
resultsAmong 361 adolescents with mood disorders, 232 (64.3%) exhibited NSSI behaviors. Analyses revealed that CT was directly associated with NSSI (β = 0.312, p < 0.001) and indirectly associated through mediation pathways (β = 0.256, p < 0.001). CT also showed direct association with depression severity (β = 0.400, p < 0.001). Depression severity was significantly associated with NSSI (β = 0.184, p = 0.042), suggesting a partial mediating role of depression severity in this relationship.
conclusionsCT shows a significant association with NSSI among adolescents with mood disorders, with depression severity serving as a partial mediator in this relationship. Active coping strategies targeting depressive symptoms in individuals with a history of CT may help reduce NSSI behaviors.
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