Evidence map›Paper›PMID 40356297›Full record

ArticleACS applied materials & interfaces2025

3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering.

Chieh-Ying Chen, Ruaina Lily Hope Gadia Moreno, Po-Yao Wang, Thanh Sang Nguyen, Jia-Lin Wu, Kuan-Hao Chen, Chih-Hwa Chen, Chia-Ying Lin, Pei-Chun Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chieh-Ying ChenGraduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Ruaina Lily Hope Gadia MorenoGraduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Po-Yao WangGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-1012-6953
Thanh Sang NguyenInternational Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0009-0008-4053-4791
Jia-Lin WuDepartment of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan.
Kuan-Hao ChenDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chih-Hwa ChenSchool of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Chia-Ying LinConvergent Bioscience and Technology Institute, Department of Biomedical Engineering and Informatics, Indiana University, Indianapolis, Indiana 46202, United States.
Pei-Chun WongGraduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-8357-5616

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-dimensional (3D) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise and customizable solutions for bone tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties for temperature-controlled bone regeneration. The AuPB-PCL scaffolds demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, and improved osteogenic potential. Photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, and mineralization. Notably, mild hyperthermia (39-41 °C) induced by laser irradiation optimized osteogenesis, while excessive temperatures (≥42.5 °C) impaired cellular function due to mitochondrial stress and oxidative damage. These findings highlight the potential of AuPB-PCL scaffolds for controlled photothermal bone regeneration, offering a promising strategy for precise, completely noninvasive stimulation of bone repair.

Indexed as

Bone and BonesGoldPolyestersPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsAlkaline PhosphataseAnimalsBone RegenerationCell ProliferationHumansMiceOsteoblastsOsteogenesisTemperatureAlkaline PhosphataseGoldpolycaprolactonePolyesters3D printinggold plasmonic blackbodyNIR laser irradiationphotothermal effectpolycaprolactone

Identifiers

PMID40356297
PMCPMC12100601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.