Evidence map›Paper›PMID 40356280›Full record

ArticlePigment cell & melanoma research2025

A Dominant Mutation in G

Philip S Goff, Peter Budd, Darren W Logan, Margaret Keighren, Marta Cantero, Lisa McKie, Lluis Montoliu, Ian J Jackson, Elena V Sviderskaya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pigment cell & melanoma research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Philip S GoffSchool of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID 0000-0003-4371-5527
Peter BuddMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Darren W LoganMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-1545-5510
Margaret KeighrenMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-8116-9670
Marta CanteroDepartment of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.ORCID 0000-0001-6554-906X
Lisa McKieMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9350-4344
Lluis MontoliuDepartment of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.ORCID 0000-0003-3941-1176
Ian J JacksonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-6526-0688
Elena V SviderskayaSchool of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID 0000-0002-4177-8236

Funding

Medical Research Council MC_UU_00007/4Spanish Ministry of Science and Innovation PID2021-127644OB-I00Wellcome TrustWellcome Trust 108429/Z/15/Z
6 · The paper itself

Abstract

We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the G

Indexed as

GTP-Binding Protein alpha Subunits, GsHair ColorMutationAgouti Signaling ProteinAnimalsChromograninsFemaleMaleMelanocytesMiceMice, Inbred C57BLReceptor, Melanocortin, Type 1Signal TransductionAgouti Signaling ProteinChromograninsGnas protein, mouseGTP-Binding Protein alpha Subunits, GsReceptor, Melanocortin, Type 1ASPG‐alpha SMC1RMcCune Albright syndromemelanocytesNDP‐MSHpigmentation

Identifiers

PMID40356280
PMCPMC12069967

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.