ArticleJournal of clinical periodontology2025
Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis.
Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Fueling failure or fostering fusion? A critical review of the potential effect of ketogenic, intermittent fasting, and low-carbohydrate diets on dental implant osseointegration.The Saudi dental journal · 2026Review
- Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis.Journal of clinical periodontology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
aimTo evaluate the effect of prolonged fasting on the oral microbiome in patients with metabolic syndrome (MetS). MATERIALS AND
methodsThis follow-up study evaluated changes in the oral microbiome in a sub-cohort of 42 patients with MetS during prolonged fasting. Periodontal parameters such as bleeding on probing (BOP), plaque index (PI) and gingival crevicular fluid (GCF) measured in Periotron units (PU) as well as supra- and subgingival plaque samples were taken at baseline (T1), after 5-10 days of prolonged fasting (T2) and at 4-5-month follow-up (T3). Sequencing of the V4 hypervariable region of the 16S rRNA gene was performed to analyse the microbiome composition.
resultsSignificant reductions were observed in BOP: 36.4% ± 18.2% to 30.4% ± 15.6% (p = 0.01), PI: 66.9% ± 19.5% to 58.8% ± 23.4% (p < 0.01) and GCF: 83.6 ± 27.8 PU to 67.9 ± 30.3 PU (p < 0.01) post fasting. Microbiome α- and β-diversity did not change significantly. However, significant changes in specific bacterial genera were noted: Lachnospiraceae [G-3] increased only in subgingival samples; Eikenella and Peptostreptococcaceae [XI][G-7] increased; while Mitsuokella and Atopobium decreased in both sub- and supra-gingival samples.
conclusionWithin the constraints of this analysis, prolonged fasting was found to be associated with reduced periodontal inflammation and selected shifts in the oral microbial composition. Larger controlled trials are needed to confirm these exploratory findings and determine their clinical relevance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.