ReviewThe European journal of neuroscience2025
Development of GABAergic Interneurons in the Human Cerebral Cortex.
Review in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Developmental alcohol exposure: Impacts on medial prefrontal cortex morphology and the excitatory-inhibitory balance.Progress in neuro-psychopharmacology & biological psychiatry · 2026Review
- The Value of Transvaginal Neurosonography in the Detection of Fetal Ganglionic Eminence Abnormalities.Life (Basel, Switzerland) · 2026Review
- Regional specialization of upper-layer inhibitory interneuron organization in the human prefrontal cortex.Journal of anatomy · 2026Article
- Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation.bioRxiv : the preprint server for biology · 2026Article
- Cortical Type: The Basis for a Modern Neurodevelopmental Synthesis (Ontogeny, Phylogeny, Synaptic Connectivity) of the Human Cerebral Cortex.The Journal of comparative neurology · 2026Review
- A Single-Cell and Spatial 3D Multi-omic Atlas of Developing Human Basal Ganglia and Inhibitory Neurons.bioRxiv : the preprint server for biology · 2026Article
- High-frequency, high-intensity electrical stimulation selectively activates human fast-spiking interneurons.Frontiers in synaptic neuroscience · 2026Article
- Modular inhibitory coding in binary networks.Frontiers in network physiology · 2026Article
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- Neurochemical-hemodynamic-electrophysiological coupling in the neonatal brain: a multimodal MRS-fMRI-EEG investigation.Frontiers in neuroscience · 2026Article
- Early life shifts in cortical inhibitory-excitatory balance underlies sensitive periods and skill development.Frontiers in cellular neuroscience · 2026Article
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1 author.
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Abstract
GABAergic interneurons are critical regulators of information processing in the cerebral cortex. They constitute a heterogeneous group of neurons with unique spatial and temporal capabilities to control information flow and influence neural network dynamics through inhibitory and disinhibitory mechanisms. Interneuron diversity is largely conserved between rodents and primates, which indicates that the addition of new types of GABAergic neurons is not the most critical innovation of the primate cortex. In contrast, interneurons are much more abundant and seem more widely interconnected in the cerebral cortex of primates than in rodents, suggesting selective evolutionary pressure in the mechanisms regulating the generation, survival and maturation of cortical interneurons. Recent studies are beginning to shed light on the cellular and molecular mechanisms controlling the development of cortical interneurons in humans, from their generation in the embryonic telencephalon to their early integration in cortical networks. These studies identified many features in the development of human cortical interneurons that are shared with other mammals, along with distinctive features that seem characteristic of the primate brain, such as a previously unrecognised protracted period of neurogenesis and migration that extends the earliest stages of interneuron development into the first months of postnatal life in humans.
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Registered trials
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