SynthesisPsycho-oncology2025
Mental Health in Familial Adenomatous Polyposis: A Systematic Review.
Synthesis in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mental- and physical health, and general well-being in patients with polyposis syndromes: a scoping review.Familial cancer · 2026Article
- Advances in Hereditary Colorectal Cancer: How Precision Medicine Is Changing the Game.Cancers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveFamilial adenomatous polyposis (FAP) is a hereditary disposition causing a nearly 100% risk of developing colorectal cancer without treatment. Therefore lifelong endoscopic surveillance and prophylactic colectomy, generally before the age of 30, are offered. Children of genetically confirmed FAP-patients have a 50% risk of inheriting the disease. It is a challenge to cope with the burden of FAP. The aim of this systematic review was to study the literature on the presence of mental issues, including anxiety, depression, distress, intellectual disability, and symptoms in the autism spectrum in FAP-patients.
methodsA search was performed in PubMed, EMBASE and Cochrane Library to retrieve English studies on mental health and FAP from inception to May 2024.
resultsOf the 2045 identified papers, 35 met our criteria. Most papers did not show increased levels in mean scores of distress, anxiety or depression. However, subgroups with high levels of distress, anxiety and depression were identified, specifically around the time of genetic testing and bowel surgery. Associations between FAP and co-occurrent psychiatric disorders and lower cognitive function were suggested.
conclusionsIn conclusion, there is some evidence that co-occurrent psychiatric disorders and intellectual deficits are more prevalent in FAP-patients compared to the general population. During genetic testing and bowel surgery, distress, anxiety and depressive symptoms in subgroups of FAP-patients might be increased. As FAP is a rare disease and sample sizes were small, firm conclusions cannot be drawn. Large prospective studies on mental health issues over time are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.