Evidence map›Paper›PMID 40356028›Full record

ArticleJournal of cellular and molecular medicine2025

Sex-Dependent Paracrine Effect of Conditioned Media From Adipose Tissue Derived Mesenchymal Stem Cells on Prostate Cancer Cells.

Akram Mirzaei, Rahil Mashhadi, Ziba Aghsaeifard, Mehrnaz Izadi, Seyedeh Negin Hashemi Dougaheh, Reza Omid, Fateme Guitynavard, Parsa Nikoofar, Seyed Mohammad Kazem Aghamir

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Akram MirzaeiUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-2219-999X
Rahil MashhadiUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ziba AghsaeifardUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mehrnaz IzadiUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Seyedeh Negin Hashemi DougahehUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Reza OmidUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Fateme GuitynavardUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Parsa NikoofarDepartment of Urology, Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada.
Seyed Mohammad Kazem AghamirUrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-1611-0362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the different behaviour of cells in response to diseases in different conditions and sex hormone-dependent cancers, we addressed the possible effect of the sex of the source of these cells from adipose tissue on prostate cancer cells. In this in vitro study, we evaluated the effects of male and female MSC Conditioned Media (MCM, FCM) on prostate cancer cells. The assessment included Hoechst dye staining, a scratch-wound assay, a colony formation assay, and a flow cytometric analysis of apoptosis and the cell cycle. We also performed real-time PCR to examine various genes, including apoptosis-related genes, epithelial-mesenchymal transition (EMT) genes, angiogenesis-related genes, and cell growth and survival biomarkers. Our results indicated that the IC

Indexed as

Adipose TissueMesenchymal Stem CellsParacrine CommunicationProstatic NeoplasmsApoptosisCell Line, TumorCell ProliferationCulture Media, ConditionedEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMaleCulture Media, Conditionedgene expressionmesenchymal stem cellsprostate cancersex‐dependent paracrine

Identifiers

PMID40356028
PMCPMC12069013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.