Evidence map›Paper›PMID 40356025›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Public attitudes toward dementia risk prediction: A mixed-methods study.

Jacqueline J Claus, Mathijs T Rosbergen, Marije J Splinter, Jolande van Heemst, M Arfan Ikram, Meike W Vernooij, Frank J Wolters

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Public attitudes toward dementia risk prediction: A mixed-methods study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacqueline J ClausDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-7047-7064
Mathijs T RosbergenDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Marije J SplinterDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Jolande van HeemstDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Meike W VernooijDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Frank J WoltersDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-2226-4050

Funding

Alzheimer Nederland WE.03-2023-16Alzheimer's Association AARF-22-924982Cure Alzheimer's FundDutch Heart Foundation CVON2018-28Dutch National Dementia StrategyEdwin Bouw Fonds and Gieskes-StrijbisfondsErasmus Medical Center and Erasmus UniversityErasmus Trust FundEuropean CommissionHealth∼Holland, Topsector Life Sciences & Health #LSHM20106Ministry of Education, Culture, and ScienceMinistry of Health, Welfare, and SportsNetherlands Consortium of Dementia Cohorts 73305095005Netherlands Genomics InitiativeNetherlands Organisation for Health Research and Development 09150162010108Netherlands Organisation for Health Research and Development BIRD-NL-10510032120005Netherlands Organization for Health Research and DevelopmentOrganization for Scientific ResearchResearch Institute for Diseases in the Elderlythe Municipality of RotterdamZonMw #73305095007
6 · The paper itself

Abstract

introductionNumerous dementia risk prediction models have been developed, but uptake in clinical practice is poor.

methodsWe determined public attitude toward dementia risk prediction through the means of a focus group (n = 9) and subsequent online survey (n = 687). Thematic content analysis was used for focus group data and descriptive statistics for survey responses.

resultsFocus group participants expressed reluctance in knowing dementia risk due to fear, emotional burden, and belief that prevention was impossible. Conversely, practical benefits and maximizing present quality of life motivated others to know dementia risk. Of survey respondents, 66.1% would want to know their 10-year risk at present, increasing to 82.3% if preventive medication were available. People perceived their 10-year risk as rather high, yet lower still than their own personal threshold for considering preventive action. DISCUSSION: Development and implementation of dementia risk prediction tools require attention for personal actionability and emotional impact of risk communication. HIGHLIGHTS: Among citizens with a particular interest in dementia, a large group is keen to learn their personal dementia risk, particularly when effective preventive measures are available. In focus group participants, hesitancy to learn about dementia risk was common, driven by fear, emotional burden, and doubts about the effectiveness of preventive interventions. The majority of survey participants (72%) believed a healthy lifestyle could reduce dementia risk. People perceived their 10-year risk as rather high, yet lower still than their own personal threshold for considering preventive action.

Indexed as

DementiaHealth Knowledge, Attitudes, PracticePublic OpinionAdultAgedAged, 80 and overFemaleFocus GroupsHumansMaleMiddle AgedRisk AssessmentRisk FactorsSurveys and Questionnairesdementiaimplementationmixed‐methodspublic perspectivesrisk prediction

Identifiers

PMID40356025
PMCPMC12069024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.