ArticleNutrition & metabolism2025
Taurine corrects lupus CD4
Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms.Amino acids · 2026Pooled it
- Screening of diagnostic biomarkers for taurine metabolism-related genes in lupus nephritis and analysis of immune infiltration.International urology and nephrology · 2026Article
- A novel high-entropy TiVCrMoCJournal of pharmaceutical analysis · 2026Article
- The microbiota-systemic lupus erythematosus axis: mechanisms, diagnostics, and therapeutic frontiers.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThis study was designed to explore the metabolism features in systemic lupus erythematosus (SLE) and to investigate the role and regulatory mechanism of taurine in the control of CD4
methodsMetabolomic profiles of sera from SLE patients and healthy controls (HCs) were analyzed by mass spectrometry. The therapeutic effects of taurine in vivo were observed in resiquimod (R848) induced mice, and the effects of taurine on various functions of CD4
resultsBoth untargeted metabolomics assays and independent sample validation showed that serum levels of taurine were reduced in SLE patients compared to HCs (P<0.0001), which was inversely correlated with disease activity scores (P<0.05). Taurine supplementation relieved the progression of lupus in R848 induced mice, characterized by a decrease in anti-dsDNA (P<0.01) and proteinuria (P<0.05) and a reduction in the severity of nephritis (P<0.05). And, taurine supplementation improved the differentiation of cell subsets such as Th17 (P<0.001) and Treg cells (P<0.001) in these mice. In vitro, taurine suppressed reactive oxygen species production (P<0.001), proliferation (P<0.0001) and senescence (P<0.0001) of mouse spleen cells. The level of pS6 (P<0.0001) but not AKT in CD4
conclusionTaurine may play a therapeutic role by ameliorating CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.