Evidence map›Paper›PMID 40355921›Full record

ArticleBMC chemistry2025

Thyrotoxicosis antidote assay along with concurrent medication; chromatographic and environmental issues.

Raghda A Emam, Aml A Emam, Rehab M Abdelfatah, Basma H Anwar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raghda A EmamPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., Beni-Suef, 62514, Egypt.
Aml A EmamPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., Beni-Suef, 62514, Egypt.
Rehab M AbdelfatahPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., Beni-Suef, 62514, Egypt. r_magdy26@yahoo.com.
Basma H AnwarPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., Beni-Suef, 62514, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A thionamide medication, Methimazole (MTZ), is a crucial antidote of thyroid hormone in cases of toxic nodular goiter or thyrotoxicosis by decreasing thyroid hormone synthesis. Propranolol (PRP), a beta blocker, is commonly co-administered with MTZ for controlling tachycardia associated with hyperthyroidism. Quantitative determination and tracing of MTZ in plasma in the presence of its co-administered medication, like PRP, is of paramount importance due to the reported toxic manifestations related to MTZ long-term administration that include agranulocytosis, hepatitis, arthritis, and skin rashes. An environmentally benign FDA-validated TLC densitometric approach was established for the first time for simultaneous and quantitative analysis of MTZ and PRP in pure form and spiked human plasma. The work is considered a mimetic study for their co-administration. Successful resolution between them was achieved on Merck

Indexed as

Greenness assessmentHydrocortisone acetateMethimazolePropranololSpiked human plasmaThin layer chromatography

Identifiers

PMID40355921
PMCPMC12070551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.