ArticleBMC psychiatry2025
Weight restoration in patients with anorexia nervosa after stereotactic surgery and brain morphometric insights.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The effects of neuromodulation interventions on the eating behaviors of patients with eating disorders compared to healthy controls, sham therapies, and other therapeutic approaches: A systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
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12 authors.
Funding
Abstract
backgroundBilateral anterior capsulotomy and deep brain stimulation (DBS) of the nucleus accumbens (NAc) represent investigational treatment options for severe, treatment-refractory anorexia nervosa (AN). However, follow-up studies evaluating postoperative outcomes in these patients remain limited, and the clinical and neuroanatomical characteristics associated with treatment response have yet to be elucidated.
methodsThe retrospective study analyzed the preoperative imaging data of AN patients who underwent bilateral anterior capsulotomy or nucleus accumbens (NAc) DBS from 2019 to 2023. Voxel-based morphometry (VBM) was employed to assess structural differences between AN patients and healthy controls (HCs), as well as to identify brain regions associated with postoperative changes in body mass index (BMI).
resultsNineteen patients were included in the analysis, six of whom received NAc DBS. The mean (standard deviation, SD) BMI of patients significantly increased from 13.4 (2.5) kg/m² preoperatively to 20.7 (5.3) kg/m² postoperatively (t = 5.45, p < 0.001). A significant smaller gray matter volume was observed in widespread regions in AN patients compared to HCs including the cerebellum, the thalamus, the temporal, orbital frontal gyrus and the sensorimotor gyrus in VBM analysis (P
conclusionsBoth ablative and DBS surgeries demonstrate efficacy in promoting weight restoration in severe AN patients. The structural integrity of specific brain regions may play a role in predicting postoperative BMI recovery. Further studies with a larger number of patients are warranted to better evaluate the outcome of the surgeries and the predictive value of the imaging characteristics.
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