Evidence map›Paper›PMID 40355868›Full record

ArticleMolecular brain2025

Synergistic actions of corticosterone and BDNF on rat hippocampal LTP.

Jonathan S Thacker, Liam T Ralph, Laura Koek, Aram Abbasian, Luis B Bettio, Ashleigh E Smith, John Georgiou, Brian R Christie, Graham L Collingridge

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jonathan S ThackerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada.
Liam T Ralph *Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada.
Laura Koek *Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada.
Aram Abbasian *Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada.
Luis B BettioDivision of Medical Sciences, University of Victoria, Victoria, BC, Canada.
Ashleigh E SmithAlliance for Research in Exercise Nutrition and Activity (ARENA) Research Group, Division of Health Sciences, University of South Australia, Adelaide, Australia.
John GeorgiouLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada.
Brian R ChristieDivision of Medical Sciences, University of Victoria, Victoria, BC, Canada.
Graham L CollingridgeLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada. Collingridge@lunenfeld.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise evokes many physiological changes, including the release of hormones and growth factors that are known to improve cognition via unknown mechanisms. Here, we have compared the ability of two physiologically relevant factors, corticosterone (CORT) and brain-derived neurotrophic factor (BDNF), to affect long-term potentiation (LTP) in the hippocampus. Using a compressed theta-burst stimulation (cTBS) protocol, we found that CORT has no effect on LTP, BDNF enhances LTP and combined CORT + BDNF treatment results in significantly greater LTP. We also find that CORT + BDNF, but not either compound alone, results in phosphorylation of protein kinase A (PKA). These findings show that BDNF and CORT act synergistically to enhance LTP at these synapses, potentially via a PKA-dependent mechanism. Such a synergistic action could underlie the positive cognitive effects of exercise.

Indexed as

Brain-Derived Neurotrophic FactorCorticosteroneHippocampusLong-Term PotentiationAnimalsCyclic AMP-Dependent Protein KinasesDrug SynergismMalePhosphorylationRatsRats, Sprague-DawleyBrain-Derived Neurotrophic FactorCorticosteroneCyclic AMP-Dependent Protein Kinases

Identifiers

PMID40355868
PMCPMC12070750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.