Evidence map›Paper›PMID 40355852›Full record

Trial reportBMC psychiatry2025

Bright light therapy in Parkinson's disease: a pilot study on visual pathway improvements.

Wei-Ye Xie, Hui Lou, Jia-Ying Liu, Jie-Yun Yin, Tian-Qi Zhang, Cheng-Jie Mao, Fen Wang, Chun-Feng Liu, Yun Shen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei-Ye Xie *Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Hui Lou *Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Jia-Ying LiuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Jie-Yun YinJiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, Soochow University, Suzhou, 215123, China.
Tian-Qi ZhangDepartment of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Cheng-Jie MaoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Fen WangJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Chun-Feng LiuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. liuchunfeng@suda.edu.cn.
Yun ShenDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. shenyun127@126.com.

Funding

National Key R&D Program of China 2022YFC2503904Science and Technology Innovation Project of Xiongan New Area 2023XAGG0073Suzhou Key Laboratory SZS2023015the National Natural Science Foundation of China 82401741the National Natural Science Foundation of China 82471269the Postgraduate Research & Practice Innovation Program of Jiangsu Province SJCX23_1675
6 · The paper itself

Abstract

backgroundBright light therapy (BLT) has been proved to have beneficial effects on Parkinson's disease (PD), the mechanisms remained unclear. Improvements of visual pathways might be key to BLT.

objectiveThe aim of this study is to validate whether BLT improves clinical symptoms in PD and explore the possible mechanisms of visual pathways evaluated by optical coherence tomography (OCT), pattern electroretinogram (PERG) and visual evoked potentials (VEP).

methodsTwenty-three PD patients were enrolled in this crossover randomized placebo-controlled study. Participants received either one month of BLT or dim light therapy (DLT), separated by one-month wash-out period, followed by another intervention. Participants underwent clinical scales, and visual-related evaluations including OCT, PERG and VEP before and after each intervention. Mixed-effects regression models were used to determine the effect between BLT and DLT on improving the differentials of clinical scales (Δscales), OCT (Δretinal thickness), PERG (ΔPERG values) and VEP (ΔP100 latencies). Correlations between clinical symptoms and visual evaluations improvements were analyzed in PD patients receiving BLT.

resultsExcessive daytime sleepiness, anxiety, life quality and autonomic function were improved after BLT. Compared with DLT, bilateral ΔN95 latencies for PERG and ΔP100 latencies for VEP were improved after BLT. We did not observe the changes of four quadrants retinal nerve fiber layer (RNFL) thickness after BLT or DLT.

conclusionsBLT is a valuable and safe non-pharmacological intervention for improving visual function in PD patients. SIGNIFICANCE: These findings extend neural mechanisms of BLT to visual pathways improvements.

Indexed as

Parkinson DiseasePhototherapyVisual PathwaysAgedCross-Over StudiesElectroretinographyEvoked Potentials, VisualFemaleHumansMaleMiddle AgedPilot ProjectsTomography, Optical CoherenceTreatment OutcomeBright light therapyOptical coherence tomographyParkinson’s diseasePattern electroretinogramRandomized crossover controlled trialVisual evoked potentials

Identifiers

PMID40355852
PMCPMC12070497

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.