Evidence map›Paper›PMID 40355786›Full record

ArticleJournal of neuro-oncology2025

Financial toxicity in pediatric and adolescent neurosurgical oncology.

Alexandra M Giantini-Larsen, Samantha Brown, Anne S Reiner, Stephanie Doyle Giandalone, Kyle Zappi, Zaki Abou-Mrad, Yasmin Khakoo, Ira J Dunkel, Matthias A Karajannis, Sameer F Sait and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Advances in the management of pediatric low-grade glioma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  2. [Current status and prospects of family financial toxicity in childhood malignancies].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexandra M Giantini-LarsenDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Samantha BrownDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anne S ReinerDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stephanie Doyle GiandalonePatient Financial Services, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kyle ZappiDepartment of Neurosurgery, Weill Cornell Medicine, New York, NY, USA.
Zaki Abou-MradDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yasmin KhakooDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ira J DunkelDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Matthias A KarajannisDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sameer F SaitDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Caitlin E HoffmanDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jeffrey P GreenfieldDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mark M SouweidaneDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
W Christopher NewmanDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. newmanw@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundFinancial toxicity (FT) encompasses the negative impact of medical costs on patients. In-depth analysis of FT in pediatric and adolescent neurosurgical oncology has not been performed. The aim of this study was to determine the incidence of FT in this population.

designA retrospective review of medical and financial services data was conducted at Memorial Sloan Kettering Cancer Center of patients under 21 years of age who underwent neurosurgery for a cancer-related diagnosis from 2016 to 2020.

results294 surgical procedures across 202 patients were analyzed. 16% (33/202) of patients experienced FT in the two years prior to the first neurosurgical procedure, and the most common toxicity identifier was utilization of the financial assistance program (45%). For all 202 patients, the 2-year cumulative incidence of FT following first neurosurgical procedure was 19% (CI:14%,24%). Among patients who survived for at least 2 years after surgery, 34% (29/86) experienced FT with the most common toxicity being having bills sent to collections (34%). Most patients who experienced FT had at least one commercial insurance policy. Presence of pre-operative FT was associated with a significantly higher cumulative incidence of post-operative FT (2-year estimates: pre-operative FT 61% (95%CI: [41%,75%]) vs. no pre-operative FT 11% (95%CI: [7%,16%]), p < 0.001).

conclusionFT poses challenges in the pediatric neurosurgical oncology population. Pre-operative FT significantly influences post-operative FT. Most patients who experienced FT had at least one commercial insurance plan, providing evidence that even patients with insurance are not immune to FT.

Indexed as

Brain NeoplasmsFinancial StressHealth Care CostsNeurosurgical ProceduresAdolescentChildChild, PreschoolFemaleFollow-Up StudiesHumansIncidenceInfantMaleRetrospective StudiesYoung AdultFinancial toxicityNeurosurgeryPediatric

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.