Evidence map›Paper›PMID 40355740›Full record

GuidelineSurgical endoscopy2025

EAES rapid guideline: complete mesocolic excision for right-sided colon cancer-with SAGES and ESCP participation.

Stavros A Antoniou, Francesco Maria Carrano, Alexander A Tzanis, Konstantinos Perivoliotis, Sunjay S Kumar, Christos Christogiannis, Dimitris Mavridis, Bright Huo, Nicole Bouvy, Niki Christou and 12 more

Abstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Stavros A AntoniouDepartment of Surgery, Papageorgiou General Hospital, Thessaloniki, Greece. stavros.antoniou@hotmail.com.ORCID http://orcid.org/0000-0002-4630-6748
Francesco Maria CarranoDepartment of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, St Andrea Hospital, Sapienza University, Rome, Italy.
Alexander A Tzanis1 st Department of Obstetrics and Gynaecology, Alexandra University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos PerivoliotisDepartment of Surgery, General Hospital of Volos, Volos, Greece.
Sunjay S KumarDepartment of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Christos ChristogiannisDepartment of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.
Dimitris MavridisDepartment of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.
Bright HuoDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Canada.
Nicole BouvyDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Niki ChristouDivision of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland.
Suzanne DorePatient Representative, Rayne, Essex, UK.
Audrius DulskasNational Cancer Center, Affiliate of Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania.
Christos Kontovounisios2nd Surgical Department, Evangelismos General Hospital, Athens, Greece.
Tim LubbersDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Francesco PalazzoDepartment of Surgery, General Hospital of Volos, Volos, Greece.
Philip QuirkePathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Dimitra RepanaSchool of Cancer and Pharmaceutical Sciences King's College London, New Hunt's House, Guy's Campus, London, UK.
Monica TerlizzoDepartment of Pathology, The Royal Marsden NHS Foundation Trust, London, UK.
Bethany J SlaterDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Ivan D FlorezDepartment of Pediatrics, University of Antioquia, Medellin, Colombia.
Monica OrtenziDepartment of General and Emergency Surgery, Polytechnic University of Marche, Ancona, Italy.
Tan ArulampalamSchool of Medicine, Anglia Ruskin University, Chelmsford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplete mesocolic excision (CME) is a surgical technique that aims to improve oncological outcomes of right-sided colon cancer resections. However, CME's technical complexity, surgical risks, and need for specialized training, present challenges. Also, variations in technical aspects and implementation lead to inconsistent outcomes.

objectiveTo develop evidence-informed clinical practice recommendations on complete mesocolic excision for right-sided colon cancer, aiming to address whether laparoscopic CME should be preferred over standard laparoscopic right hemicolectomy for right-sided colon cancer.

methodsThe present guideline adheres to GRADE, AGREE-S, and Cochrane standards, using MAGICapp for development. The steering group included colorectal and general surgeons, supported by a Guidelines International Network-certified lead guideline developer, trainee methodologists, systematic reviewers and statisticians. The guideline panel included surgeons, oncologists, a pathologist, and a patient partner. It provides recommendations based on a linked systematic review, appraisal of benefits and harms, the certainty of the evidence, patient values and preferences, acceptability, feasibility, use of resources, and equity.

resultsA conditional recommendation is issued in favor of CME for patients undergoing right hemicolectomy for right-sided colon cancer where expertise is available, based on low-to-moderate certainty evidence. The panel suggests CME is acceptable to stakeholders and feasible, despite potential equity issues due to variable expertise availability. There is insufficient evidence to recommend CME based on tumor location or cancer stage. A conditional recommendation means that the majority of well-informed patients, surgeons and other stakeholders, would opt for the recommended course of action, but discussion of relevant benefits and harms is advised prior to decisions. The full guideline with user-friendly decision aids is available in https://app.magicapp.org/#/guideline/EaG1dL .

conclusionsThis guideline provides evidence-informed recommendations on the management of right-sided colon cancer, developed in line with the highest quality methodological and reporting standards, and informed by an interdisciplinary panel of stakeholders.

Indexed as

ColectomyColonic NeoplasmsLaparoscopyMesocolonHumansCMEColon cancerComplete mesocolic excisionGuidelineRight colectomy

Identifiers

PMID40355740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.