ArticleEvidence-based dentistry2025
Eggshell-derived hydroxyapatite as a biomaterial in dentistry: a scoping review of synthesis, properties and applications.
Article in Evidence-based dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07183514 (Clinical and Radiographic Evaluation of Eggshell-derived Calcium Hydroxyapatite Verses Calcium Hydroxide as In-direct Pulp Capping Agent in Permanent Molars), which is not on this map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Radiographic Evaluation of Eggshell-derived Calcium Hydroxyapatite Verses Calcium Hydroxide as In-direct Pulp Capping Agent in Permanent Molars
Who cites it
7 citing papers in PubMed.
- Eggshell powder as a biomimetic alternative to biodentine in primary teeth pulpotomy: a comparative clinical and radiographic study.Scientific reports · 2026Trial
- AI for bioactive materials: From material design to biological applications.Bioactive materials · 2026Review
- Article
- In vitro assessment of experimental bioactive tooth gel formulas containing L-arginine, ginger and eggshell for remineralization and anti-bacterial effect.Scientific reports · 2026Article
- Hydroxyapatite Nanoparticle Modification of 3D-Printed Crown Resin: Effects of Concentration on Surface Roughness and Vickers Hardness After Thermocycling.Journal of functional biomaterials · 2026Article
- Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.Biomimetics (Basel, Switzerland) · 2026Article
- A comparative evaluation of eggshell derived hydroxyapatite and demineralized freeze-dried bone allograft in alveolar ridge preservation - a randomized clinical trial.Biomaterial investigations in dentistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundHydroxyapatite (HAp) derived from chicken eggshells has recently gained significant interest in tissue engineering and regenerative medicine. This paper aims to review the synthesis, properties and applications of eggshell-derived hydroxyapatite (E-HAp) in dentistry.
methodsA comprehensive literature search was conducted in PubMed and Scopus databases, along with a grey literature search. The references of selected studies were also manually reviewed to identify additional relevant articles. No restrictions were applied for language or publication year. Two independent reviewers carried out the study selection and data extraction processes.
resultsSeventeen studies met the inclusion criteria and were included in the qualitative analysis. Most studies were in vitro investigations focused on applications such as dentinal tubule sealing (n = 4) and remineralization of initial enamel caries lesions (n = 4). E-HAp was also studied for tissue engineering applications, including alveolar ridge preservation as a bone graft material (n = 5) and periodontal regeneration (n = 2). Additional applications included regenerative endodontics (n = 3) and use as a pulp capping agent (n = 2).
conclusionE-HAp shows a wide range of applications in dentistry, particularly in tissue engineering and regenerative dentistry, marking it as a promising biomaterial in dentistry.
Indexed as
Identifiers
40355679What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.