Evidence map›Paper›PMID 40355670›Full record

ArticleAIDS and behavior2025

Acceptability and Feasibility of Remote PrEP Visits for Adolescent Girls and Young Women in South Africa.

Makhosazane Nomhle Ndimande-Khoza, Jennifer Velloza, Hlukelo Chauke, Lisa Mills, Nicole Poovan, Nontokozo Ndlovu, Tessa Concepcion, Sybil Hosek, Connie Celum, Sinead Delany-Moretlwe

Abstract read
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In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Makhosazane Nomhle Ndimande-KhozaWits RHI, Faculty of Health Sciences, University of the Witwatersrand, 22 Esselen Street, Hillbrow, Johannesburg, 2000, South Africa. nkhoza@cartafrica.org.ORCID http://orcid.org/0000-0003-1312-7783
Jennifer VellozaDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Hlukelo ChaukeWits RHI, Faculty of Health Sciences, University of the Witwatersrand, 22 Esselen Street, Hillbrow, Johannesburg, 2000, South Africa.
Lisa MillsWits RHI, Faculty of Health Sciences, University of the Witwatersrand, 22 Esselen Street, Hillbrow, Johannesburg, 2000, South Africa.
Nicole PoovanWits RHI, Faculty of Health Sciences, University of the Witwatersrand, 22 Esselen Street, Hillbrow, Johannesburg, 2000, South Africa.
Nontokozo NdlovuWits RHI, Faculty of Health Sciences, University of the Witwatersrand, 22 Esselen Street, Hillbrow, Johannesburg, 2000, South Africa.
Tessa ConcepcionDepartment of Global Health, University of Washington, Seattle, WA, USA.
Sybil HosekDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Connie CelumDepartment of Medicine, University of Washington, Seattle, WA, USA.
Sinead Delany-MoretlweWits RHI, Faculty of Health Sciences, University of the Witwatersrand, 22 Esselen Street, Hillbrow, Johannesburg, 2000, South Africa.

Funding

PrEP for Young South African Women: Evaluating Uptake by Risk Screening or a Decision Support Tool and Scaled Adherence Support Using a SMART DesignR01MH114544 · NIMH · UNIVERSITY OF WASHINGTON · PI CELUM, CONNIE L, DELANY-MORETLWE, SINEAD · 2017 to 2021
$3.1M
Adolescent HIV Prevention and Treatment Implementation Science Alliance 67155NIMH NIH HHS R01 MH114544
6 · The paper itself

Abstract

The World Health Organization recommends differentiated service delivery (DSD) models for HIV prevention, including alternatives to clinic-based PrEP services. This study assessed the acceptability and feasibility of remote PrEP delivery-including HIV and pregnancy self-testing, and phone-based adherence counselling-among adolescent girls and young women (AGYW) in Johannesburg. The research was nested within the PrEP SMART trial (2019-2022), which evaluated scalable adherence support strategies for AGYW aged 18-25. During COVID-19 lockdowns, PrEP refills and testing kits were delivered to participants' homes, and counselling was provided by phone. Using a phenomenological qualitative method, we conducted in-depth interviews with AGYW (n = 14) who had the option to complete remote PrEP visits (accepting or declining), study staff (n = 12), and key informants (n = 10) involved in PrEP programming. Thematic analysis explored experiences of remote delivery, focusing on acceptability and feasibility. AGYW found remote PrEP visits convenient, empowering, and time-saving. Procedures such as self-testing and phone counselling were generally acceptable, though some expressed anxiety about performing tests incorrectly and concerns over privacy, stigma, and unintentional disclosure of PrEP use at home. About half still preferred clinic-based visits. Staff and key informants recognized benefits, but highlighted challenges related to cost, sustainability, and provider workload. Suggestions for improvement included integrating contraception and partnering with community organizations. In conclusion, remote PrEP delivery is acceptable and feasible for many AGYW but not universally suitable. These findings support the inclusion of remote PrEP options in DSD models, with attention to privacy concerns and support for self-testing in this age group.

Indexed as

Anti-HIV AgentsHIV InfectionsPatient Acceptance of Health CarePre-Exposure ProphylaxisAdolescentAdultCounselingCOVID-19Feasibility StudiesFemaleHumansPregnancyQualitative ResearchSARS-CoV-2South AfricaTelemedicineAnti-HIV AgentsAdolescent girls and young womenDifferentiated service deliveryHIV self-testingPrEPRemote health care servicesSouth Africa

Identifiers

PMID40355670

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.