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ArticleJournal of hematopathology2025

Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology.

Alfonso Orozco-Collazo, María José Lizardo-Thiebaud, Sergio Rodríguez-Rodríguez, Daniel Montante-Montes de Oca, Berta Riveros-Gilardi, Beatriz Sánchez-Hernández, Alec Seidman-Sorsby, Cinthya Monroy-Ramos, José Jesús Sandoval-López, Isabel García-Carrera and 1 more

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Article in Journal of hematopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Alfonso Orozco-CollazoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
María José Lizardo-ThiebaudInstituto Nacional de Pediatria, Mexico City, Mexico.
Sergio Rodríguez-RodríguezInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Daniel Montante-Montes de OcaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Berta Riveros-GilardiInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Beatriz Sánchez-HernándezInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Alec Seidman-SorsbyInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Cinthya Monroy-RamosInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
José Jesús Sandoval-LópezInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Isabel García-CarreraInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Déborah Martínez-BañosInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. deborah.martinezb@incmnsz.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Castleman disease is a clinicopathological entity that shares features with hematological, rheumatological, and infectious diseases, making accurate diagnosis essential. The objective of this study is to characterize the clinical and pathological characteristics of CD in a Mexican cohort. A retrospective study was conducted on adult Mexican patients diagnosed with unicentric (UCD) and multicentric (MCD) Castleman disease from 1985 to 2023. Clinical and histopathological characteristics typical of UCD and MCD were observed. POEMS-associated MCD showed a higher relapse rate. The mixed histopathological variant was more prevalent in MCD. Immunohistochemical expression of VEGF-A was elevated in all CD cases. A multidisciplinary diagnostic approach is crucial for accurately categorizing CD. The mixed histopathological variant was more common than previously reported, especially in MCD. Further studies are needed to validate VEGF-A as a biomarker for CD.

Indexed as

Castleman DiseaseAdultAgedFemaleHispanic or LatinoHumansMaleMexicoMiddle AgedRetrospective StudiesVascular Endothelial Growth Factor AYoung AdultVascular Endothelial Growth Factor AVEGFA protein, humanCastleman diseaseHistopathologyPOEMS-associated MCDRelapse rateVEGF

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.