ArticleInternational journal of obesity (2005)2025
Evaluating the obesity paradox in patients with sepsis and cancer.
Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Body mass index and hospital mortality in mechanically ventilated patients with acute hypoxaemic respiratory failure: A retrospective cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Risk Factors for Adverse Outcomes in Cancer Patients With Sepsis.Journal of clinical medicine research · 2026Article
- The obesity paradox in primary Sjögren's disease: immunometabolic associations of chemerin, platelet count, and statin use.Frontiers in immunology · 2026Article
- Association of Body Mass Index with 28-Day Mortality in Adult Intensive Care Patients with Sepsis: A Retrospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Development and Validation of a 28-Day Mortality Prediction Model for Patients with Sepsis Complicated by Autoimmune Diseases Using Two Machine Learning Methods.Journal of inflammation research · 2026Article
- Obesity Is Associated with a Lower Risk of Mortality and Readmission in Heart Failure Patients with Diabetes.Biomedicines · 2025Article
- Multiplexed longitudinal analysis of the cellular and microbial dynamics of acute polymicrobial sepsis in mice.Frontiers in immunology · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundThe obesity paradox, where higher body mass index (BMI) is associated with improved survival, is observed in sepsis and cancer individually. However, its effect in patients with both conditions is unclear. The objective of this study is to evaluate the obesity paradox in intensive care unit (ICU) patients with sepsis and cancer and examine whether BMI's impact on mortality varies across patient phenotypes.
methodsData from the Medical Information Mart for Intensive Care IV database were analyzed. Patients were categorized by BMI into underweight (<18.5 kg/m
resultsAmong 3914 patients, obesity was associated with lower mortality. Clustering revealed four distinct phenotypes, with the protective effect of obesity being more evident in patients with lower Sequential Organ Failure Assessment (SOFA) scores (Cluster1, Cluster2 and Cluster3).
conclusionsThe obesity paradox is evident in both short-term outcome (28-day mortality) and long-term outcomes (6-month and 1-year mortality) among patients with sepsis and cancer, particularly in those presenting with lower disease severity. These findings highlight the need for personalized treatment approaches in this complex patient population.
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