Evidence map›Paper›PMID 40355558›Full record

ArticleThe EMBO journal2025

YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ.

Lihua Wang, Yuqin Wang, Kaixin Ding, Zhenzhi Li, Zhipeng Zhang, Xinzhi Li, Yue Song, Liwei Xie, Zheng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. NBiomolecules · 2026
    Review
  5. Review
  6. YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lihua Wang *HIT Center for Life Sciences, School of Life Science and Technology, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, 150001, China.
Yuqin Wang *HIT Center for Life Sciences, School of Life Science and Technology, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, 150001, China.
Kaixin Ding *HIT Center for Life Sciences, School of Life Science and Technology, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, 150001, China.
Zhenzhi Li *HIT Center for Life Sciences, School of Life Science and Technology, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, 150001, China.
Zhipeng ZhangHIT Center for Life Sciences, School of Life Science and Technology, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, 150001, China.ORCID http://orcid.org/0009-0002-4658-3582
Xinzhi LiNHC Key Laboratory of Cell Transplantation, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Yue SongHIT Center for Life Sciences, School of Life Science and Technology, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, 150001, China.
Liwei XieGuangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, China.
Zheng ChenHIT Center for Life Sciences, School of Life Science and Technology, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, 150001, China. chenzheng@hit.edu.cn.ORCID http://orcid.org/0000-0001-7129-6644

Funding

GDAS' project of science and technology development and young talent project of GDAS 2024GDASZH-2024010102 and 2024GDASQNRC-0104Heilongjiang Chunyan Team CYCX24020MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) HIT.OCEF.2025001MOST | National Natural Science Foundation of China (NSFC) 32371198MOST | National Natural Science Foundation of China (NSFC) 82401019
6 · The paper itself

Abstract

Brown adipose tissue (BAT) plays a vital role in non-shivering thermogenesis and energy metabolism and is influenced by factors like environmental temperature, ageing, and obesity. However, the molecular mechanisms behind BAT development and thermogenesis are not fully understood. Our study identifies the m

Indexed as

Adipose Tissue, BrownPPAR gammaThermogenesisAnimalsEnergy MetabolismHumansMiceMice, Inbred C57BLMice, KnockoutProteolysisUbiquitin-Protein LigasesPPAR gammaPparg protein, mouseUbiquitin-Protein LigasesBrown Adipose TissueIntrinsically Disordered RegionPPARγThermogenesisYTHDC1

Identifiers

PMID40355558
PMCPMC12170836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.