Evidence map›Paper›PMID 40355539›Full record

ArticlePediatric research2026

Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study.

Hamza Abbasi, Clariss Blanco, Arun Prasath, Mary Kasu, Sylvia Gugino, Justin Helman, Nicole Bradley, Lori Nielsen, Rocco A Paluch, Praveen Chandrasekharan and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Hamza AbbasiJohn R. Oishei Children's Hospital, Neonatology Department, Buffalo, NY, USA. hamzaabb@buffalo.edu.
Clariss BlancoJohn R. Oishei Children's Hospital, Neonatology Department, Buffalo, NY, USA.
Arun PrasathJohn R. Oishei Children's Hospital, Neonatology Department, Buffalo, NY, USA.
Mary KasuJohn R. Oishei Children's Hospital, Neonatology Department, Buffalo, NY, USA.
Sylvia GuginoState University of New York at Buffalo, Buffalo, NY, USA.
Justin HelmanState University of New York at Buffalo, Buffalo, NY, USA.
Nicole BradleyState University of New York at Buffalo, Buffalo, NY, USA.
Lori NielsenState University of New York at Buffalo, Buffalo, NY, USA.
Rocco A PaluchState University of New York at Buffalo, Buffalo, NY, USA.
Praveen ChandrasekharanJohn R. Oishei Children's Hospital, Neonatology Department, Buffalo, NY, USA.
Munmun RawatJohn R. Oishei Children's Hospital, Neonatology Department, Buffalo, NY, USA.

Funding

Optimizing Chest Compressions for Bradycardia during Neonatal ResuscitationR01HD104909 · NICHD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CHANDRASEKHARAN, PRAVEEN · 2021 to 2025
$1.5M
NICHD NIH HHS R01 HD104909
6 · The paper itself

Abstract

backgroundThe efficacy of Laryngeal Mask Airway (LMA) epinephrine during neonatal resuscitation has not been studied. We hypothesize that LMA epinephrine is as effective as endotracheal tube (ETT) epinephrine.

methodsSixteen fetal lambs were randomized in ETT or LMA group for ventilation and airway epinephrine administration after cord occlusion to induce complete cardiac arrest. Lambs were delivered and instrumented to continuously record pulmonary and systemic hemodynamics. After 5 min of cardiac arrest, lambs were resuscitated per NRP guidelines. Blood gases and plasma epinephrine levels were regularly measured during resuscitation.

resultsBaseline characteristics were similar between the two groups. Incidence of return of spontaneous circulation (ROSC) was 5/8 (62.5%) in both groups; p = 1.00. Mean time to ROSC was similar in both groups; 6 minutes and 42 ± 65 s in the LMA group, and 6 min and 46 ± 51 s in the ETT group; p = 0.92. There was no difference in plasma epinephrine levels at baseline (LMA 0.7 ± 0.5 vs. ETT 0.8 ± 0.2 ng/mL; p = 0.88) and post-airway epinephrine administration (LMA 8.0 ± 3.1 vs. ETT 7.8 ± 4.6 ng/mL; p = 0.85).

conclusionThe use of LMA epinephrine for neonatal resuscitation is a suitable alternative to ETT epinephrine. IMPACT: The Neonatal Resuscitation Program (NRP) recommends a dose of airway epinephrine to be administered via the endotracheal tube (ETT) while intravenous access is being established. Endotracheal intubation is a highly skilled procedure. Laryngeal mask airway (LMA) is as effective in delivering positive pressure ventilation (PPV) and requires less training to achieve adequate competency to secure a stable airway. We show that LMA is a similar method to deliver epinephrine during neonatal resuscitation in the ovine model.

Indexed as

Cardiopulmonary ResuscitationEpinephrineHeart ArrestLaryngeal MasksResuscitationAnimalsAnimals, NewbornFemaleHemodynamicsIntubation, IntratrachealReturn of Spontaneous CirculationSheepEpinephrine

Identifiers

PMID40355539
PMCPMC13433248

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.