Evidence map›Paper›PMID 40355491›Full record

ArticleScientific reports2025

The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster.

Douglas Lisboa Ramalho, Jadyellen Rondon Silva, Maria Eduarda Monteiro Martins Dos Santos, Maria Eduarda Silva Soares, Andrielle Adelina Teodoro Jesus, Thiago Henrique Oliveira Alves, Michelle Fernanda Brugnera, Sidnei Moura, Anderson Oliveira Souza

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Douglas Lisboa RamalhoMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Jadyellen Rondon SilvaMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Maria Eduarda Monteiro Martins Dos SantosMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Maria Eduarda Silva SoaresMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Andrielle Adelina Teodoro JesusMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Thiago Henrique Oliveira AlvesMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Michelle Fernanda BrugneraBiocide Residue Analysis Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Sidnei MouraBiotechnology of Natural and Synthetic Products Laboratory, Institute of Biotechnology, University of Caxias do Sul, Caxias do Sul, Brazil.
Anderson Oliveira SouzaMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil. anderson.souza@ufmt.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodegradation is a promising technique for remediating contaminated environmental matrices. It demonstrates significant potential in transforming organic contaminants into carbon dioxide, water, and inorganic anions through degradation reactions that involve transient oxidizing species, mainly hydroxyl radicals generated by ultraviolet (UV) irradiation. In this study, we investigated whether the photodegradation of Paraquat (PQ) with UV irradiation reduced its toxicity in Drosophila melanogaster. Our results indicate that ingesting PQ degradation products by larvae resulted in a low axial ratio (pupal volume). In the adults, it resulted in markedly diminished climbing ability in a time-dependent manner after 10 days of feeding. In addition, exposure of D. melanogaster to photodegradation of PQ reduced acetylcholinesterase and citrate synthase activities but improved oxidative stress, as evidenced by protein carbonyl, and lactate production. These results suggest that the photodegradation of PQ with UV irradiation produced PQ fragments with higher toxicity than PQ, while the precise mechanism of its action requires further investigation.

Indexed as

Drosophila melanogasterHerbicidesParaquatAcetylcholinesteraseAnimalsLarvaOxidative StressPhotolysisUltraviolet RaysAcetylcholinesteraseHerbicidesParaquatDegradation productsDrosophila melanogasterNeurotoxicityPhotodegradationUV irradiation

Identifiers

PMID40355491
PMCPMC12069668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.