Evidence map›Paper›PMID 40355374›Full record

ArticleBMJ paediatrics open2025

Less invasive surfactant administration for meconium aspiration syndrome.

Arun Prasath, Etze Chotzoglou, Asmahan Ahmad, Efren Diaz, Patti Burchfield, L Steven Brown, David B Nelson, Katherine Stumpf, Venkatakrishna Kakkilaya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arun PrasathDivision of Neonatology, University of Texas Southwestern Medical Center, Dallas, USA Arun.Prasath@UTSouthwestern.edu.
Etze ChotzoglouColumbia University Medical Center, New York, New York, USA.ORCID http://orcid.org/0000-0003-1016-5397
Asmahan AhmadUT Southwestern Medical Center, Dallas, Texas, USA.
Efren DiazUT Southwestern Medical Center, Dallas, Texas, USA.
Patti BurchfieldUT Southwestern Medical Center, Dallas, Texas, USA.
L Steven BrownDepartment of Pediatrics, Parkland Health and Hospital System, Dallas, Texas, USA.
David B NelsonUT Southwestern Medical Center, Dallas, Texas, USA.
Katherine StumpfUT Southwestern Medical Center, Dallas, Texas, USA.
Venkatakrishna KakkilayaUT Southwestern Medical Center, Dallas, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of less invasive surfactant administration (LISA) using a thin catheter in the management of meconium aspiration syndrome (MAS) is unclear. STUDY

designA retrospective study of infants with MAS admitted between January 2016 and December 2023. Relevant characteristics and outcomes were compared between a group of infants receiving surfactant in conjunction with mechanical ventilation (MV) via an endotracheal tube (ETT-surf) and receiving LISA. Infants intubated at birth were excluded.

resultsOf the 113 infants admitted on continuous positive airway pressure (CPAP), 61 did not receive surfactant, 26 belonged to the ETT-surf group and 26 to the LISA group. Compared with the ETT-surf, a higher proportion of infants in the LISA group were exposed to chorioamnionitis and received a lower median fraction of inspired oxygen at birth and before surfactant therapy. Notably, infants in the LISA group had a lower need for MV (100 vs 23%, p<0.001), inhaled nitric oxide (iNO) (46% vs 12%, p=0.01) and a shorter median duration of hospital stay (14 vs 24 days, p=0.04). A subgroup analysis of infants with hypoxic respiratory failure on admission showed lower need for MV and duration of hospital stay with the LISA group compared with the ETT-surf group.

conclusionsLISA was associated with a lower need for MV, iNO and a shorter duration of hospital stay in a select group of infants with MAS. Further prospective studies are necessary to evaluate the role of LISA in MAS.

Indexed as

Meconium Aspiration SyndromePulmonary SurfactantsAdministration, InhalationContinuous Positive Airway PressureFemaleHumansInfant, NewbornIntubation, IntratrachealLength of StayMaleNitric OxideRespiration, ArtificialRetrospective StudiesTreatment OutcomeNitric OxidePulmonary SurfactantsNeonatologyResuscitationSyndrome

Identifiers

PMID40355374
PMCPMC12083396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.