ArticleThoracic cancer2025
Circulating Tumor DNA Dynamic Changes in Esophageal Squamous Cell Carcinoma Receiving Immunochemotherapy.
Article in Thoracic cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Perioperative circulating tumor DNA profiling for recurrence risk in esophageal squamous cell carcinoma: moving toward a biology-driven surveillance model.Annals of translational medicine · 2026Article
- Real-world experience with first-line pembrolizumab plus chemotherapy in Vietnamese patients with stage IV esophageal squamous cell carcinoma.Frontiers in immunology · 2026Article
- Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact.Cancer metastasis reviews · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundImmune checkpoint inhibitors have revolutionized the treatment strategy of esophageal squamous cell carcinoma (ESCC). The value of ctDNA dynamic changes in ESCC patients treated with immunochemotherapy was not clear.
methodsA retrospective analysis was performed to analyze the association of ctDNA dynamic changes with the treatment efficacy of immunochemotherapy in patients with locally advanced, metastatic, or recurrent ESCC and who received immunochemotherapy at the Department of Medical Oncology, National Cancer Center from June 2023 to December 2024. Tumor mutation burden (TMB) and PD-L1 expression of tumor tissue were also explored.
results57 patients with paired ctDNA at baseline and during treatment were analyzed. We found that patients with negative ctDNA during treatment demonstrated a higher tumor regression rate (96.8% vs. 73.1%; p = 0.018) and a higher cCR rate (45.2% vs. 15.4%; p = 0.022). Additionally, patients with continuously negative ctDNA (p = 0.033) or experienced ctDNA clearance during treatment (p = 0.043) had a higher cCR rate compared to those with persistently positive ctDNA. Moreover, among patients with TP53 mutations at baseline, those with TP53 mutations cleared during treatment showed a higher tumor regression rate (88.9% vs. 54.5%; p = 0.031) and cCR rate (33.3% vs. 0%; p = 0.038) compared to patients with persistent TP53 mutations. No correlation was observed between TMB and treatment efficacy, while a higher cCR rate was observed in patients with PD-L1 CPS ≥ 15 (63.6% vs. 24.4%; p = 0.027).
conclusionsctDNA dynamic changes demonstrated potential predictive value for the efficacy of immunochemotherapy in patients with ESCC. Further exploration through larger-scale studies is necessary.
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