Evidence map›Paper›PMID 40355123›Full record

ArticleThe journal of obstetrics and gynaecology research2025

Ischemic placental disease as a risk factor for bronchopulmonary dysplasia in extremely preterm infants.

Yu Ariyoshi, Takayuki Iriyama, Seisuke Sayama, Eri Suzuki-Ariyoshi, Eriko Yano, Haruka Matsui, Kensuke Suzuki, Ayako Hashimoto, Mari Ichinose, Masatake Toshimitsu and 12 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yu AriyoshiDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Takayuki IriyamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7970-6695
Seisuke SayamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Eri Suzuki-AriyoshiDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Eriko YanoDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Haruka MatsuiDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kensuke SuzukiDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Ayako HashimotoDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Mari IchinoseDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2974-9109
Masatake ToshimitsuDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-0509-7812
Takahiro SeyamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kenbun SoneDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Osamu Wada-HiraikeDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-3458-6711
Atsushi ItoDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshihiko ShitaraDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Keiichi KumasawaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-0865-604X
Akio IshiguroDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Satsuki KakiuchiDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kohei KashimaDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Yasushi HirotaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Naoto TakahashiDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Yutaka OsugaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6660-1066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aims to investigate the association between placental insufficiency and complications in extremely preterm infants in the context of ischemic placental disease (IPD), including preeclampsia, small-for-gestational-age (SGA), and placental abruption.

methodsInfants born between 22 and 28 weeks of gestation were classified into IPD and non-IPD groups, matched 1:1 by gestational age and sex. The incidence of neonatal complications was analyzed.

resultsAnalysis included 48 infants in each group. The IPD group had a significantly lower birth weight (IPD vs. non-IPD: 679 g vs. 979 g, p < 0.001), whereas the non-IPD group was characterized by a higher prevalence of spontaneous preterm births (12% vs. 79%, p < 0.001) and a significantly higher incidence of histological chorioamnionitis (CAM) (15% vs. 50%, p < 0.001). The IPD group showed a significantly higher incidence of bronchopulmonary dysplasia (BPD) compared to the non-IPD group (85% vs. 48%, p < 0.001), with no significant differences in other complications such as intraventricular hemorrhage, retinopathy of prematurity, and necrotizing enterocolitis. Logistic regression identified IPD as a significant risk factor for BPD (odds ratio [OR] [95% confidence interval]: 9.4 [2.8-31.8], p < 0.001), along with preeclampsia (OR: 4.9 [1.3-18.3], p = 0.01) and SGA (OR: 31.9 [5.9-171], p < 0.001). CAM was not associated with BPD (OR: 0.6 [0.2-1.7], p = 0.45).

conclusionsPlacental insufficiency, manifesting as IPD, is strongly associated with an increased risk of BPD in extremely preterm infants.

Indexed as

Bronchopulmonary DysplasiaInfant, Extremely PrematureIschemiaPlacenta DiseasesPlacental InsufficiencyAdultFemaleHumansInfant, NewbornInfant, Small for Gestational AgeMalePregnancyRisk Factorsbronchopulmonary dysplasiaischemic placental diseaseplacental insufficiencypreeclampsiasmall‐for‐gestational‐age

Identifiers

PMID40355123
PMCPMC12068935

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.