Evidence map›Paper›PMID 40355084›Full record

ArticleIndian heart journal

Determination of Induction Time in Adult Patients with Valvular Heart Disease.

Tanya Mital, Suruchi Hasija, Sambhunath Das, Sandeep Chauhan, Maroof A Khan

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Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Tanya MitalDepartment of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: tanyamital3@gmail.com.
Suruchi HasijaDepartment of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
Sambhunath DasDepartment of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
Sandeep ChauhanDepartment of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
Maroof A KhanDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIntravenous anaesthetics induce loss of consciousness in one arm-brain circulation time. As the circulatory transit time in patients with mitral stenosis (MS) and aortic stenosis (AS) is increased, the delivery of anaesthetics to the brain may be prolonged and consequently the onset of hypnosis. This study aimed to compare the induction time in patients with and without valvular heart disease (VHD).

designProspective, single-center, open-label analytical study.

settingIt was conducted in adult patients undergoing elective cardiac surgery.

participantsThe patients (n = 144) were segregated into three groups; Group 1 - Stenotic VHD (MS, AS), Group 2 - Regurgitant VHD (Mitral Regurgitation, Aortic Regurgitation), and Group 3 - Control (coronary artery disease).

methodGeneral anaesthesia was induced with intravenous thiopental 4mg kg MAIN

resultsPatients in Group 1 (n = 48) had significantly prolonged induction time (99.6 ± 12.9s; p < 0.001) compared to the other two groups (n = 48 each) (68.5 ± 9.6s in Group 2 and 70.4 ± 11.8s in Group 3). Time required for BIS to fall below 60 was significantly longer in Group 1 (139.4 ± 24.6s; p < 0.001) compared to Group 2 (90.4 ± 6.3s) and Group 3 (92.1 ± 12s).

conclusionThe induction time was prolonged in patients with stenotic VHD compared to patients with regurgitant VHD or those without VHD.

Indexed as

Anesthesia, GeneralCardiac Surgical ProceduresHeart Valve DiseasesAdultAnesthetics, IntravenousFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesTime FactorsAnesthetics, IntravenousAnaesthesia InductionBispectral indexHypnosisIntravenous anaestheticsValvular heart disease

Identifiers

PMID40355084
PMCPMC12327519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.