Evidence map›Paper›PMID 40355061›Full record

ArticleEnvironmental research2025

Sex-specific associations between per- and polyfluoroalkyl substance exposure and epigenetic age: Findings from the National Health and Nutrition Examination survey 1999-2000.

Dennis Khodasevich, Anne K Bozack, Belinda L Needham, David H Rehkopf, Andres Cardenas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dennis KhodasevichDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA. Electronic address: denkhod@stanford.edu.
Anne K BozackDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Belinda L NeedhamDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
David H RehkopfDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA; Department of Health Policy, Stanford University, Palo Alto, CA, USA; Department of Medicine (Primary Care and Population Health), Stanford University, Palo Alto, CA, USA; Department of Pediatrics, Stanford University, Palo Alto, CA, USA; Department of Sociology, Stanford University, Palo Alto, CA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA; Department of Pediatrics, Stanford University, Palo Alto, CA, USA.

Funding

Race/Ethnicity, DNA Methylation, and Disparities in Cardiovascular Mortality: NHANES 1999-2002R01MD011721 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEEDHAM, BELINDA L., REHKOPF, DAVID H · 2017 to 2021
$3.1M
Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American ChildrenR01MD016595 · NIMHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andres Cardenas, Julianna Deardorff · 2022 to 2026
$3.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
Epigenetic biomarkers of cardiovascular risk in African American WomenR01HL175681 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Andres Cardenas, Nora Franceschini · 2024 to 2026
$1.2M
Mentored Training in Molecular Epidemiology of Chronic Kidney Disease in Diverse PopulationsK26DK138425 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nora Franceschini · 2023 to 2026
$277k
Early life influences on Epigenetic Aging in Mexican-American childrenR03AG067064 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2020 to 2021
$159k
NHLBI NIH HHS R01 HL175681NIA NIH HHS R03 AG067064NIDDK NIH HHS K26 DK138425NIEHS NIH HHS R01 ES031259NIMHD NIH HHS R01 MD011721NIMHD NIH HHS R01 MD016595
6 · The paper itself

Abstract

Per-and polyfluoroalkyl substances (PFAS) are a pervasive family of synthetic compounds with a wide range of reported health effects. Epigenetic clocks, DNA methylation-based predictors of chronological and biological age, are promising biomarkers for characterizing biological aging in humans. The potential impact of PFAS exposure on epigenetic aging in the general US population remains unclear. In the 1999-2000 National Health and Nutrition Examination Survey (NHANES) cycle (N = 262), eleven PFASs were measured in serum and DNA methylation was measured in blood with the EPICv1 array. Seven epigenetic clocks and their respective epigenetic age acceleration (EAA) measures were calculated. Survey-design weighted generalized linear regression models were used to test adjusted associations between individual log

Indexed as

AgingEnvironmental ExposureEnvironmental PollutantsEpigenesis, GeneticFluorocarbonsAdultAgedDNA MethylationFemaleHumansMaleMiddle AgedNutrition SurveysSex FactorsUnited StatesEnvironmental PollutantsFluorocarbonsAgingEnvironmental exposuresEpigenetic ageEpigenetic clocksPFAS

Identifiers

PMID40355061
PMCPMC12136984

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.