Evidence map›Paper›PMID 40354935›Full record

ArticleJournal of advanced research2026

Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes.

Yong-Qi Guo, Meng-Hang Wang, Ning Tang, Yu-Bo Zhao, Li-Jing Wo, De-Xin Liang, Rui Huang, Yan-Dong Tang, Ying-Jie Sun, Xin Yin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yong-Qi GuoState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
Meng-Hang WangState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
Ning TangShanghai Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Shanghai, China.
Yu-Bo ZhaoState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
Li-Jing WoState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
De-Xin LiangState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
Rui HuangState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
Yan-Dong TangState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China. Electronic address: tangyandong@caas.cn.
Ying-Jie SunShanghai Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Shanghai, China. Electronic address: sunyingjie@caas.cn.
Xin YinState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China. Electronic address: yinxin@caas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlpha-herpesvirus poses significant health risks to humans and challenges to animal husbandry. Currently, the clinically approved antiviral drug Acyclovir exhibits limitations, including drug resistance and adverse effects. The development of broad-spectrum antiviral agents against alpha-herpesvirus is urgently needed.

objectiveThis study aimed to discover a novel antiviral drug with the capacity to broadly inhibit various alpha-herpesviruses.

methodsIn this study, we conducted a high-content screening of 1,500 chemical compounds to identify potential antiviral candidates. The antiviral mechanisms were explored using phenotypic experiments, untargeted metabolomics, and molecular docking.

resultsWe discovered that Antimycin A effectively inhibits the replication of various alpha-herpesviruses, including herpes simplex virus 1 (HSV-1), bovine herpesvirus 1 (BHV-1), and pseudorabies virus (PRV). Our study revealed that Antimycin A inhibits viral replication by disrupting the formation of pyrimidinosomes that are essential for efficient viral infection. Finally, Antimycin A effectively inhibited viral infection, prevented tissue damage, and enhanced survival in PRV-infected BALB/c mice, confirming its in vivo efficacy.

conclusionAntimycin A emerges as a promising lead candidate for the development of antiviral therapies against alpha-herpesvirus infections.

Indexed as

AlphaherpesvirinaeAntimycin AAntiviral AgentsHerpesviridae InfectionsVirus ReplicationAnimalsHerpesvirus 1, SuidHumansMiceMice, Inbred BALB CMolecular Docking SimulationAntimycin AAntiviral AgentsAlpha-herpesvirusesAntimycin ADHODHPyrimidinosomesVDAC3

Identifiers

PMID40354935
PMCPMC12869216

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.