Evidence map›Paper›PMID 40354933›Full record

ArticleJournal of advanced research2026

SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations.

Wenliang Che, Shuai Guo, Yanqun Wang, Xiaohua Wan, Bingyu Tan, Hailing Li, Jiasuer Alifu, Mengyun Zhu, Zesong Chen, Peiyao Li and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Wenliang CheDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Shuai GuoCryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China; School of Life Science, Southern University of Science and Technology, Shenzhen, China.
Yanqun WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaohua WanSchool of Medical Technology, Beijing Institute of Technology, Beijing, China.
Bingyu TanShanghai NanoPort, Thermo Fisher Scientific Inc., Shanghai, China.
Hailing LiDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Jiasuer AlifuDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Mengyun ZhuDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Zesong ChenCryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China.
Peiyao LiCryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China.
Lei ZhangCryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China.
Zhaoyong ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yiliang WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaohan HuangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xinsheng WangSchool of Medical Technology, Beijing Institute of Technology, Beijing, China.
Jian ZhuCryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China.
Xijiang PanShanghai NanoPort, Thermo Fisher Scientific Inc., Shanghai, China.
Fa ZhangSchool of Medical Technology, Beijing Institute of Technology, Beijing, China.
Peiyi WangCryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China.
Sen-Fang SuiCryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China; School of Life Science, Southern University of Science and Technology, Shenzhen, China. Electronic address: suisf@tsinghua.edu.cn.
Jincun ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou National Laboratory, Bio-Island, Guangzhou, China. Electronic address: zhaojincun@gird.cn.
Yawei XuDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: xuyawei@tongji.edu.cn.
Zheng LiuDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Cryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, China. Electronic address: liuz3@sustech.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWith the COVID-19 pandemic becoming endemic, vigilance for Long COVID-related cardiovascular issues remains essential, though their specific pathophysiology is largely unexplored.

objectivesOur study investigates the persistent cardiovascular symptoms observed in individuals long after contracting SARS-CoV-2, a condition commonly referred to as "Long COVID", which has significantly affected millions globally.

methodsWe meticulously describe the cardiovascular outcomes in five patients, encompassing a range of severe conditions such as sudden cardiac death during exercise, coronary atherosclerotic heart disease, palpitation, chest tightness, and acute myocarditis.

resultsAll five patients were diagnosed with myocarditis, confirmed through endomyocardial biopsy and histochemical staining, which identified inflammatory cell infiltration in their heart tissue. Crucially, electron microscopy revealed widespread mitochondrial vacuolations and the presence of myofilament degradation within the cardiomyocytes of these patients. These findings were mirrored in SARS-CoV-2-infected mice, suggesting a potential underlying cellular mechanism for the cardiac effects associated with Long COVID.

conclusionOur findings demonstrate a profound impact of SARS-CoV-2 on mitochondrial integrity, shedding light on the cardiovascular implications of Long COVID.

Indexed as

Cardiovascular DiseasesCOVID-19MitochondriaMitochondria, HeartMyocarditisMyocytes, CardiacSARS-CoV-2AdultAgedAnimalsFemaleHumansMaleMiceMiddle AgedEndomyocardial biopsyLong COVIDMitochondria disorderSARS-COV-2

Identifiers

PMID40354933
PMCPMC12869202

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.