ArticleInternational dental journal2025
Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.
Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Partial radicular versus coronal pulpotomy using chitosan and platelet-rich fibrin in vital permanent molars with irreversible pulpitis, with or without associated apical periodontitis: A randomized controlled trial.Journal of conservative dentistry and endodontics · 2026Article
- Targeting Dental Pulp Stem Cell Senescence: A Potential Strategy for Improving Regenerative Endodontic Procedures.Bioengineering (Basel, Switzerland) · 2026Article
- Cellular senescence in the dental pulp and its implications for endodontics: a scoping review.Clinical oral investigations · 2026Article
- Decoding signaling crosstalk in pulpitis: pathogenesis and precision therapeutics.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate the effects of Biodentine on human Dental Pulp Stem Cells (hDPSCs) proliferation and senescence and explore the underlying anti-aging mechanism.
methodshDPSCs were isolated from two groups of patients aged 18 to 27 and 60 to 70 years and treated with Biodentine extract. The optimal concentration of Biodentine extract was determined using the CCK-8 assay. Biodentine treatment on hDPSCs proliferation and aging was assessed using qRT-PCR and Western blot. The small molecule inhibitor XAV939, targeting the Wnt/β-catenin signaling pathway, was added to investigate the anti-aging mechanism of Biodentine in hDPSCs.
resultsThe isolated hDPSCs exhibited mesenchymal stem cells (MSCs) characteristics, and the proportion of S-phased cells decreased significantly in the aged group. Biodentine promoted hDPSCs proliferation, with the most pronounced effect observed at 0.2 mg/mL. qRT-PCR showed that Biodentine enhanced the expression of odonto/osteogenesis-related genes. Senescence-associated β-galactosidase staining and Western blot analysis further demonstrated the significant anti-aging effect of Biodentine on hDPSCs. Western blot revealed that Biodentine exerted its anti-aging effect through the Wnt/β-catenin signaling pathway.
conclusionThe study demonstrated that Biodentine promotes proliferation and exerts anti-aging effects on hDPSCs through the Wnt/β-catenin pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.