Evidence map›Paper›PMID 40354538›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant.

Brenda Yang, Natalie Rutkowski, Anna Ruta, Elise Gray-Gaillard, David R Maestas, Sean H Kelly, Kavita Krishnan, Xinqun Wu, Shaoguang Wu, Allen Chen and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Antibiotic-induced microbiota depletion impairs the proregenerative response to a biological scaffold.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Brenda YangDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Natalie RutkowskiDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Anna RutaDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Elise Gray-GaillardDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
David R MaestasDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.ORCID 0000-0002-8207-1835
Sean H KellyDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Kavita KrishnanDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.ORCID 0000-0003-1345-0249
Xinqun WuDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Shaoguang WuDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Allen ChenDepartment of Biomedical Engineering, Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218.
Joscelyn C MejíasDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Joshua S T HooksDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Isabel VanderzeeDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Patricia MensahDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Nazmiye CelikDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Marie EricDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Peter AbrahamDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.
Ada TamDepartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Franck HousseauDepartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-7028-3953
Drew M PardollDepartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Cynthia L SearsDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0003-4059-1661
Jennifer H ElisseeffDepartment of Biomedical Engineering, Cellular and Molecular Medicine, or Ophthalmology, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231.

Funding

Biomaterials-directed regenerative immunotherapiesDP1AR076959 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2019 to 2023
$5.7M
Age and sex differences in the immune response to synthetic materialsK99AG081564 · NIA · JOHNS HOPKINS UNIVERSITY · PI MEJIAS, JOSCELYN CLARALUZ · 2023 to 2024
$202k
NIAMS NIH HHS DP1 AR076959NIA NIH HHS K99 AG081564NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) DGE1746891NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) DGE2139757
6 · The paper itself

Abstract

The gut microbiota influences systemic immunity and the function of distal tissues, including the brain, liver, skin, lung, and muscle. However, the role of the gut microbiota in the foreign body response and fibrosis is largely unexplored. To investigate this connection, we perturbed the homeostasis of the murine gut microbiota via infection with the pathogenic bacterial species enterotoxigenic

Indexed as

Bacteroides InfectionsBiocompatible MaterialsDysbiosisForeign-Body ReactionGastrointestinal MicrobiomeAnimalsBacteroides fragilisMiceMice, Inbred C57BLPolyestersProstheses and ImplantsBiocompatible MaterialspolycaprolactonePolyestersbiomaterialsforeign body responsegut microbiotaimmune responseinfection

Identifiers

PMID40354538
PMCPMC12107164

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.