Evidence map›Paper›PMID 40354512›Full record

ArticleChemMedChem2025

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium Tuberculosis: Progress Toward Novel Antitubercular Agents.

Sanderson D Calixto, Juliane S Falcão, Stella S Antunes, Marlon H Araujo, Alexandre L B Cunha, David R Martins, Sarah M R Nascimento, Thatiana L B V Simão, Elena B Lasunskaia, Nelilma C Romeiro and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sanderson D CalixtoLaboratório de Produtos Bioativos, Instituto de Ciências Farmacêuticas, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, 27930-560, Brazil.
Juliane S FalcãoLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Stella S AntunesLaboratório Integrado de Computação Científica, Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, 27930-560, Brazil.
Marlon H AraujoLaboratório de Produtos Bioativos, Instituto de Ciências Farmacêuticas, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, 27930-560, Brazil.
Alexandre L B CunhaLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
David R MartinsLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Sarah M R NascimentoLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Thatiana L B V SimãoLaboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro, 28013-602, Brazil.
Elena B LasunskaiaLaboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro, 28013-602, Brazil.
Nelilma C RomeiroLaboratório Integrado de Computação Científica, Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, 27930-560, Brazil.
Paulo R R CostaLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Michelle F MuzitanoLaboratório de Produtos Bioativos, Instituto de Ciências Farmacêuticas, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, 27930-560, Brazil.ORCID https://orcid.org/0000-0003-0155-3240
Guilherme S CaleffiLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.ORCID https://orcid.org/0000-0001-9703-3404

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 403236/2023Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.312022/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 201.136/2022, 211.560/2021, 201.179/2021Institutional Scientific Initiation Scholarship Program
6 · The paper itself

Abstract

Tuberculosis (TB) remains a leading cause of death among infectious diseases globally, necessitating new drug discovery due to rising drug-resistant strains. Homoisoflavones, a distinct subgroup of flavonoids characterized by their 3-benzylidenechroman-4-one skeleton, are promising natural products for new antimicrobials. This study explored 42 homoisoflavone derivatives as potential anti-TB agents. Several derivatives showed potent anti-Mycobacterium tuberculosis (Mtb) activity. Specifically, derivatives 19, 22, and 41 show good selectivity index and significantly inhibited the Mtb H37Rv strain (MIC

Indexed as

Antitubercular AgentsIsoflavonesMycobacterium tuberculosisAnimalsDose-Response Relationship, DrugHumansMiceMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntitubercular AgentsIsoflavonesabsorption, distribution, metabolism, excretion and toxicitydrug developmenthomoisoflavonessynthesistuberculosis

Identifiers

PMID40354512
PMCPMC12276032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.