ArticlePloS one2025
Analysis of axial shortening induced by orthokeratology lenses and its mechanical mechanisms.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta-analysis of ocular immune-related adverse events.Acta ophthalmologica · 2026Pooled it
- Efficacy and safety of low-concentration atropine combined with orthokeratology for children with myopia: a systematic review and meta-analysis of randomized controlled trials.BMC ophthalmology · 2026Pooled it
- The "Three-Tier Regulatory Network" of Orthokeratology in Myopia Control: Evidence Weight of Underlying Mechanisms, Controversies, and New Perspectives for Clinical Translation--A Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Effect of orthokeratology lens wear on axial length elongation in myopic children.Frontiers in medicine · 2026Article
- Visual Training for Myopia Control: An Independent and Additive Inhibitor of Axial Growth.Clinical optometry · 2026Article
- Machine learning identifies pupil size and corneal thickness as key predictors of axial elongation rate.PloS one · 2026Article
- Ocular Dimensional Changes After 12 Months of Orthokeratology and Single-Vision Spectacle Use: A Three-Dimensional Magnetic Resonance Imaging Study.Clinical optometry · 2026Article
- Baseline ocular biometrics in children with orthokeratology-induced axial length reduction or elongation.BMC ophthalmology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to examine the short-term axial shortening effects of orthokeratology (ortho-K) lenses and investigate their mechanical mechanisms.
methodsWe conducted a retrospective analysis on 80 myopic children, aged 8-18, who wore ortho-K lenses for one week. Axial lengths were measured pre- and post-treatment using AL-Scan Optical Biometer. We developed a finite element model of the eye using ABAQUS software to explore mechanical changes.
resultsA significant reduction in axial length was observed after one week of ortho-K lens wear, with an average decrease of 0.028 ± 0.032 mm (P = 4.02 x 10-11). Approximately 82.5% of participants exhibited axial length reduction. The biomechanical model indicated that ortho-K lenses exerted forces altering the tension dynamics within the ocular structure, notably decreasing tension in the posterior ciliary muscle-lens complex. This differential change in tension may account for the mechanical basis of the observed short-term reduction in axial length.
conclusionOrthokeratology lenses induce a short-term shortening in axial length, likely due to mechanical changes in ocular tension dynamics. The finite element model suggests that these lenses decrease posterior ciliary-lens complex tension, leading to axial shortening. These findings enhance comprehension of the mechanical basis for myopia control via ortho-K treatment, highlighting potential avenues for further applied research in myopia management.
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