Evidence map›Paper›PMID 40354378›Full record

ArticleAging and disease2025

Lanatoside C, a Novel Senolytic, Ameliorates Atherosclerosis in Mice.

Eok-Cheon Kim, Youlim Son, Seon-Hui Kim, Soo-Ji Kim, So-Young Park, Jae-Ryong Kim

Abstract read
In one paragraph

Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eok-Cheon KimDepartment of Biochemistry and Molecular Biology, Daegu 42415, Republic of Korea.
Youlim SonDepartment of Biochemistry and Molecular Biology, Daegu 42415, Republic of Korea.
Seon-Hui KimDepartment of Biochemistry and Molecular Biology, Daegu 42415, Republic of Korea.
Soo-Ji KimDepartment of Biochemistry and Molecular Biology, Daegu 42415, Republic of Korea.
So-Young ParkSenotherapy-based Metabolic Disease Control Research Center, Daegu 42415, Republic of Korea.
Jae-Ryong KimDepartment of Biochemistry and Molecular Biology, Daegu 42415, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence, a state of irreversible cell cycle arrest, contributes to aging and age-related diseases. Senolytics targeting cellular senescence could be applied to the prevention and treatment of age-related diseases. In this study, we identified lanatoside C (Lana C) as a senolytic compound. Lana C, a cardiac glycoside used for the treatment of cardiovascular diseases, is known to inhibit the transmembrane protein sodium-potassium adenosine triphosphatase (Na

Indexed as

AtherosclerosisCellular SenescenceSenotherapeuticsAnimalsApoptosisDisease Models, AnimalHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLReceptors, LDLSenotherapeutics

Identifiers

PMID40354378
PMCPMC13128220

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.