Evidence map›Paper›PMID 40354377›Full record

ReviewAging and disease2025

Pericytes in the Development and Progression of Brain Diseases.

Qingbin Wu, Xinyi Cui, Xiaochen Yuan, Jianqun Han, Hongwei Li, Ruijuan Xiu

Abstract readReview
In one paragraph

Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qingbin WuInstitute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Xinyi CuiInstitute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Xiaochen YuanInstitute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Jianqun HanInstitute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Hongwei LiInstitute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Ruijuan XiuInstitute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pericytes are microvascular cells surrounding the endothelial cells on the outside of the capillaries in the body. They are crucial cells in the formation and ensure the integrity of vascular walls in the microcirculation. The pericytes enable that by regulating blood flow, maintaining the stability of the vascular wall, and ensuring the integrity of the blood-brain barrier (BBB). It has been confirmed that pericytes are involved in many brain diseases, including Alzheimer's disease, stroke, traumatic brain injury, epilepsy, brain tumors, brain tissue infection, and hypertension. These diseases are a huge burden on global health, and they exert significant strain on healthcare systems and society because of morbidity, mortality, and their impact on the overall quality of life of the affected population. This review study summarizes and evaluates the role of pericytes in the development and progression of many brain diseases and their role in disease progression regulation mechanisms, thereby providing new insights into the potential of pericytes in treating brain diseases.

Indexed as

Brain DiseasesPericytesAnimalsBlood-Brain BarrierBrainDisease ProgressionHumans

Identifiers

PMID40354377
PMCPMC13061569

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.