Evidence map›Paper›PMID 40354313›Full record

ArticleBlood advances2025

The CLUE postsurgery VTE risk instrument for abdominal and pelvic surgery: validation of patient risk factor component.

Kari A O Tikkinen, Deborah M Siegal, P J Devereaux, Sara V Tornberg, Flavia K Borges, Sandra Ofori, Jehonathan Pinthus, Bobby Shayegan, Lauri I Lavikainen, CLUE Post-Surgery VTE Risk Instrument Group and 2 more

Abstract readValidation Study
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Article in Blood advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Kari A O TikkinenDepartment of Surgery, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-1389-8214
Deborah M SiegalDivision of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0003-3806-3245
P J DevereauxDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-2935-637X
Sara V TornbergDepartment of Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-9666-2126
Flavia K BorgesDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-5377-7612
Sandra OforiDepartment of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-1691-0979
Jehonathan PinthusDivision of Urology, Department of Surgery, Faculty of Medicine, McMaster University, Hamilton, ON, Canada.
Bobby ShayeganDivision of Urology, Department of Surgery, Faculty of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-9570-610X
Lauri I LavikainenDepartment of Surgery, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-2793-2556
CLUE Post-Surgery VTE Risk Instrument Group
Gordon H GuyattDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-2352-5718
Pavel S RoshanovPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-3908-1955

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractVenous thromboembolism (VTE) remains a major postoperative risk. Systematic reviews have established procedure-specific VTE risk estimates, which form 1 component of the CLUE postsurgery VTE risk instrument. The instrument also incorporates patient-level factors, including age (≥75 years), body mass index (≥35 kg/m2), and prior VTE, to stratify overall risk. However, the patient risk factor component has not been formally validated. Therefore, we conducted the validation using data from the VISION study, a prospective, international cohort of 11 636 patients undergoing major general abdominal, urologic, or gynecologic surgery. Thirty-day postoperative VTE incidence was analyzed using modified Poisson regression. The instrument classified patients into low- (72%), medium- (25%), and high-risk (4%) categories. VTE occurred in 97 patients (0.8%). Compared to the low-risk group, the relative risk of VTE was 1.56 (95% confidence interval [CI], 1.01-2.43) for medium-risk patients and 3.60 (95% CI, 1.90-6.83) for high-risk patients. Among patients who did not receive antithrombotic medication, relative risks increased to 1.91 for medium-risk patients and 5.41 for high-risk patients. The CLUE postsurgery VTE risk instrument, using 3 widely available patient-level factors, accurately classifies patients into substantially different categories of relative VTE risk. This validated patient component complements procedure-specific absolute risk estimates derived from prior systematic reviews. To support evidence-based thromboprophylaxis decisions, the instrument is now available through an interactive online platform (www.cluevte.org).

Indexed as

AbdomenPelvisPostoperative ComplicationsVenous ThromboembolismAgedFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk AssessmentRisk Factors

Identifiers

PMID40354313
PMCPMC12329283

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