ArticleJournal of medical Internet research2025
Clinical Value of ChatGPT for Epilepsy Presurgical Decision-Making: Systematic Evaluation of Seizure Semiology Interpretation.
Article in Journal of medical Internet research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Modern generative large language models in epilepsy care: a scoping review of current applications, challenges, and future directions.Acta epileptologica · 2026Review
- Evaluating large language models for diagnostic reasoning from unstructured clinical narratives in epilepsy.Communications medicine · 2026Article
- Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models.Annals of clinical and translational neurology · 2026Article
- AI enabled decision support systems in epilepsy surgery a scoping review.Research square · 2026Article
- Large Language Models in Clinical Neurology: A Systematic Review.Research square · 2026Article
- Knowledge graph representation of the mappings between seizure semiology and epileptogenic zones.Scientific reports · 2026Article
- Deep learning enabled decision support systems in epilepsy surgery: a scoping review.npj health systems · 2026Article
- Multimodal artificial intelligence in epilepsy: antiseizure medication response, epileptogenic zone localization, and surgical outcome prediction.Frontiers in neurology · 2026Review
- The impact of prompting on ChatGPT's adherence to status epilepticus treatment guidelines.Scientific reports · 2025Article
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Abstract
backgroundFor patients with drug-resistant focal epilepsy, surgical resection of the epileptogenic zone (EZ) is an effective treatment to control seizures. Accurate localization of the EZ is crucial and is typically achieved through comprehensive presurgical approaches such as seizure semiology interpretation, electroencephalography (EEG), magnetic resonance imaging (MRI), and intracranial EEG (iEEG). However, interpreting seizure semiology is challenging because it heavily relies on expert knowledge. The semiologies are often inconsistent and incoherent, leading to variability and potential limitations in presurgical evaluation. To overcome these challenges, advanced technologies like large language models (LLMs)-with ChatGPT being a notable example-offer valuable tools for analyzing complex textual information, making them well-suited to interpret detailed seizure semiology descriptions and accurately localize the EZ.
objectiveThis study evaluates the clinical value of ChatGPT for interpreting seizure semiology to localize EZs in presurgical assessments for patients with focal epilepsy and compares its performance with that of epileptologists.
methodsWe compiled 2 data cohorts: a publicly sourced cohort of 852 semiology-EZ pairs from 193 peer-reviewed journal publications and a private cohort of 184 semiology-EZ pairs collected from Far Eastern Memorial Hospital (FEMH) in Taiwan. ChatGPT was evaluated to predict the most likely EZ locations using 2 prompt methods: zero-shot prompting (ZSP) and few-shot prompting (FSP). To compare the performance of ChatGPT, 8 epileptologists were recruited to participate in an online survey to interpret 100 randomly selected semiology records. The responses from ChatGPT and epileptologists were compared using 3 metrics: regional sensitivity (RSens), weighted sensitivity (WSens), and net positive inference rate (NPIR).
resultsIn the publicly sourced cohort, ChatGPT demonstrated high RSens reliability, achieving 80% to 90% for the frontal and temporal lobes; 20% to 40% for the parietal lobe, occipital lobe, and insular cortex; and only 3% for the cingulate cortex. The WSens, which accounts for biased data distribution, consistently exceeded 67%, while the mean NPIR remained around 0. These evaluation results based on the private FEMH cohort are consistent with those from the publicly sourced cohort. A group t test with 1000 bootstrap samples revealed that ChatGPT-4 significantly outperformed epileptologists in RSens for the most frequently implicated EZs, such as the frontal and temporal lobes (P<.001). Additionally, ChatGPT-4 demonstrated superior overall performance in WSens (P<.001). However, no significant differences were observed between ChatGPT and the epileptologists in NPIR, highlighting comparable performance in this metric.
conclusionsChatGPT demonstrated clinical value as a tool to assist decision-making during epilepsy preoperative workups. With ongoing advancements in LLMs, their reliability and accuracy are anticipated to improve.
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