Evidence map›Paper›PMID 40353967›Full record

ArticleDoklady. Biochemistry and biophysics2025

Comparative Characteristics of Axial Spondyloarthritis and Psoriatic Arthritis with Axial Involvement.

E E Gubar, T V Korotaeva, T V Dubinina, L D Vorobyova, P O Tremaskina, E M Agafonova, Yu L Korsakova, E Yu Loginova, K V Sakharova, A O Sablina and 4 more

Abstract readComparative Study
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Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

E E GubarNasonova Research Institute of Rheumatology, Moscow, Russia. gubarelena@yandex.ru.
T V KorotaevaNasonova Research Institute of Rheumatology, Moscow, Russia.
T V DubininaNasonova Research Institute of Rheumatology, Moscow, Russia.
L D VorobyovaNasonova Research Institute of Rheumatology, Moscow, Russia.
P O TremaskinaNasonova Research Institute of Rheumatology, Moscow, Russia.
E M AgafonovaNasonova Research Institute of Rheumatology, Moscow, Russia.
Yu L KorsakovaNasonova Research Institute of Rheumatology, Moscow, Russia.
E Yu LoginovaNasonova Research Institute of Rheumatology, Moscow, Russia.
K V SakharovaNasonova Research Institute of Rheumatology, Moscow, Russia.
A O SablinaNasonova Research Institute of Rheumatology, Moscow, Russia.
A V SmirnovNasonova Research Institute of Rheumatology, Moscow, Russia.
Sh F ErdesNasonova Research Institute of Rheumatology, Moscow, Russia.
M M UrumovaNasonova Research Institute of Rheumatology, Moscow, Russia.
S I GlukhovaNasonova Research Institute of Rheumatology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to compare clinical characteristics of patients with axial spondyloarthritis (axSpA)/ankylosing spondylitis (AS) and with axial psoriatic arthritis (axPsA). MATERIALS AND

methods. A total of 100 patients were examined: 45 with axSpA/AS (group 1) and 55 with axPsA (group 2). Patients of group 1 were included according to axSpA/AS criteria; patients of group 2, according to CASPAR (ClASsification criteria for Psoriatic ARthritis) criteria, and having axial involvement (axPsA). Axial involvement was detected in case of radiologically significant sacroiliitis (SI, bilateral grade ≥2 or unilateral grade ≥3), or active MRI significant sacroiliitis, or ≥1 syndesmophyte(s) of the cervical and/or lumbar spine. Patients were evaluated for the presence of inflammatory back pain (IBP) by ASAS (Assessment of Spondyloarthritis International Society) criteria. RESULTS AND DISCUSSION. : Patients of group 1 were younger (p < 0.001), more often were HLA-B27 positive (p < 0.001), and more often had IBP (p = 0.001). Patients of group 2 had older age (> 40 years) at back pain onset (p < 0.001) and more often had peripheral arthritis (p < 0.001), dactylitis (p = 0.004), and skin psoriasis (p < 0.001). Nail psoriasis was found only in group 2 patients (p < 0.001). Group 1 patients more often had heel enthesitis (p = 0.005). Group 2 patients had worse axial disease activity scores: BASDAI (Bath Ankylosing Spondylitis Disease Activity Index; p = 0.006) and ASDAS-СRP (Ankylosing Spondylitis Disease Activity Score with C-reactive protein level determination; р < 0.001); and worse patient-reported outcomes: BASFI (Bath Ankylosing Spondylitis Functional Index; p = 0.004), patients' pain (p = 0.005) and patients' global assessments (p = 0.036). Patients of group 2 had more syndesmophytes of the lumbar (р = 0.009) and cervical (р = 0.007) spine. Only in group 2 patients, chunky "non-marginal" syndesmophytes (in 32.1%), as well as spinal lesions without sacroiliitis (in 20.0%) were found. Patients of group 2 had more joint erosions (р = 0.001), osteolysis (р = 0.015), juxta-articular bone formation (р < 0.001) and joint ankyloses (р = 0.02). All patients of group 1 and only 80% of group 2 (р = 0.003) met ASAS criteria for axSpA. AxSpA/AS and axPsA seem to be two different diseases. In our cohort of patients, axPsA patients had worse disease status compared to axSp and AS.

Indexed as

Arthritis, PsoriaticAxial SpondyloarthritisAdultBack PainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSacroiliitisaxial involvementaxial spondyloarthritispsoriatic arthritis

Identifiers

PMID40353967

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.