Evidence map›Paper›PMID 40353936›Full record

ArticleRadiological physics and technology2025

Impact of discrepancies between CT numbers of brain-tissue-equivalent density plug and actual brain tissue on dose calculation accuracy.

Shogo Tsunemine, Shuichi Ozawa, Minoru Nakao, Satoru Sugimoto, Tetsuya Tomida, Michitoshi Ito, Masumi Numano, Hideyuki Harada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiological physics and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shogo TsunemineDepartment of Radiation and Proton Therapy Office, Shizuoka Cancer Center, Shizuoka, Japan.
Shuichi OzawaHiroshima High-Precision Radiotherapy Cancer Center, Hiroshima, Japan. ozawa@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0001-5459-9846
Minoru NakaoHiroshima High-Precision Radiotherapy Cancer Center, Hiroshima, Japan.
Satoru SugimotoMedical Data Mathematical Reasoning Team, Advanced Data Science Project, Information R&D and Strategy Headquarters, RIKEN, Yokohama, Kanagawa, Japan.
Tetsuya TomidaDepartment of Radiation and Proton Therapy Office, Shizuoka Cancer Center, Shizuoka, Japan.
Michitoshi ItoDepartment of Radiation and Proton Therapy Office, Shizuoka Cancer Center, Shizuoka, Japan.
Masumi NumanoDepartment of Radiation and Proton Therapy Office, Shizuoka Cancer Center, Shizuoka, Japan.
Hideyuki HaradaDepartment of Radiation and Proton Therapy Office, Shizuoka Cancer Center, Shizuoka, Japan.

Funding

JSPS KAKENHI 24K15811
6 · The paper itself

Abstract

This study quantitatively evaluated the impact of differences in computed tomography (CT) numbers and elemental compositions between commercially available brain-tissue-equivalent density plugs (BDPs) and actual brain tissue on dose calculations in a radiation therapy treatment planning system (RTPS). The mass density and elemental composition of BDP were analyzed using elemental analysis and X-ray fluorescence spectroscopy. The CT numbers of the BDP and actual brain tissue were measured and compared, with effective atomic numbers (EANs) calculated based on compositional analysis and the International Commission on Radiological Protection Publication 110 data for brain tissues. The theoretical CT numbers were derived using the stoichiometric CT number calibration (SCC) method. The dose calculations were performed using the modified CT number-to-relative electron density (RED) and mass density (MD) conversion tables in Eclipse v16.1, employing AAA and Acuros XB algorithms, employing the physical material table in AcurosXB_13.5. The dose metrics D

Indexed as

BrainRadiation DosageRadiotherapy Planning, Computer-AssistedTomography, X-Ray ComputedAlgorithmsHumansRadiotherapy DosageBrain-tissue-equivalent density plugCT-RED/MDInhomogeneity correction

Identifiers

PMID40353936
PMCPMC12339645

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.