Evidence map›Paper›PMID 40353863›Full record

SynthesisPediatric cardiology2026

Systemic Arterial Aneurysms in Kawasaki Disease: An Important Evidence Gap.

William B Orr, Marianna Fabi, Michael Khoury, Frederic Dallaire, Deepika Thacker, Matthew D Elias, Nadine F Choueiter, Sean M Lang, Nagib Dahdah, Ashraf S Harahsheh and 27 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

William B OrrDivision of Pediatric Cardiology, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA. worr@wustl.edu.
Marianna FabiPediatric Emergency Unit, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Bologna, Italy.
Michael KhouryDivision of Pediatric Cardiology, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Frederic DallaireDepartment of Pediatrics, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Deepika ThackerNemours Children's Health, Wilmington, DE, USA.
Matthew D EliasDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Nadine F ChoueiterKravis Children's Hospital at Mount Sinai, New York, NY, USA.
Sean M LangHeart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Nagib DahdahDivision of Pediatric Cardiology, CHU Ste-Justine, University of Montreal, Montreal, QC, Canada.
Ashraf S HarahshehDivision of Cardiology, Department of Pediatrics, Children's National Hospital, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Todd T NowlenPhoenix Children's, Phoenix, AZ, USA.
Mahmoud AlsalehiKingston Health Sciences Centre, Queens University, Kingston, ON, Canada.
Nilanjana MisraDivision of Pediatric Cardiology, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, USA.
Audrey DionneDepartment of Cardiology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Paul DanceyJaneway Children's Health and Rehabilitation Centre, St. John's, NL, Canada.
Simon LeeAnn and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Geetha RaghuveerChildren's Mercy Hospital, Kansas City, MO, USA.
Kambiz NoroziDepartment of Pediatrics, Schulich School of Medicine and Dentistry, Western University, Children's Health Research Institute, London, ON, Canada.
Jacqueline R SzmuszkoviczChildren's Hospital of Los Angeles, Los Angeles, CA, USA.
Tapas MondalDivision of Cardiology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, ON, Canada.
Mark D HicarJacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Manaswitha KhareUniversity of California San Diego/Rady Children's Hospital, San Diego, CA, USA.
Seda TierneyLucile Packard Children's Hospital, Stanford University Medical Center, Palo Alto, CA, USA.
Michael A PortmanSeattle Children's Research Institute, Seattle, WA, USA.
Melissa WehrmannChildren's Nebraska, Omaha, NE, USA.
Michelle GrcicThe Heart Center at Nationwide Children's Hospital, Columbus, OH, USA.
Balasubramanian SundaramKanchi Kamakoti Childs Trust Hospital, Chennai, India.
Mona El GanzouryAin Shams University, Cairo, Egypt.
Deepa PrasadBanner Children's Hospital, Mesa, AZ, USA.
Tyler H HarrisUPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ana Caro-BarriHospital Universitario 12 de Octubre, Madrid, Spain.
Luis Martin Garrido-GarciaHospital Angeles Lomas, Hacienda de Las Palmas, Mexico, Mexico.
Elizabeth BraunlinUniversity of Minnesota, Minneapolis, MN, USA.
Daniel MaurielloJohns Hopkins All Children's Hospital, Saint Petersburg, FL, USA.
Kimberly E McHughMedical University of South Carolina, Charleston, SC, USA.
Brian W McCrindleLabatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Onbehalf of the International Kawasaki Disease Registry

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-coronary artery systemic arterial aneurysms (SAAs) are rare and an under-reported sequelae of Kawasaki disease (KD). We hypothesize that practices regarding SAA screening and management vary widely among experts and published literature. A survey was sent to members of the International KD Registry regarding their experiences and practices with SAAs in KD patients. For comparison, a systematic scoping review was conducted using PRISMA methodology, from which 25 reports with 83 patients were included. Results from each were compared. Surveys were completed by 48 (56%) of 86 IKDR investigators; 35 (73%) respondents had > 10 years of experience caring for KD patients. However, 33% of respondents had not cared for a patient with SAA. Features prompting assessment for SAA included demographics, presence and degree of coronary artery (CA) involvement, and clinical features, including prolonged/persistent fever, progressing/persistent elevation of inflammatory markers, and resistance to standard treatment. Features prompting screening were somewhat concordant with the characteristics of patients with SAA identified in the scoping review. From the survey, the initial preferred assessment included computed tomographic angiography (48%), ultrasound (29%), and magnetic resonance imaging (24%). In contrast, assessment of patients with SAA from the scoping review commonly used multiple imaging modalities. SAA often regressed, but associated complications included thrombosis, calcification, stenosis, occlusion, and collateral formation. While SAA is a known but rare complication of acute KD, there remains a gap in evidence regarding which patients are at risk, best practices for screening and management, and outcomes. Prospective cohort studies are needed.

Indexed as

AneurysmMucocutaneous Lymph Node SyndromeEvidence GapsHumansRegistriesAneurysmsKawasaki diseaseMucocutaneous lymph node syndromePediatricsSurveillance

Identifiers

PMID40353863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.